Association of the suppressor of cytokine signaling 1 (SOCS1) gene polymorphisms with acute coronary syndrome in Mexican patients

Recent studies provide evidence on the emerging role of the SOCS1 gene in the development and progression of atherosclerotic lesions. This gene encodes for the suppressor of the cytokine signaling-1 protein that interacts directly with the Janus kinases that are essential intracellular mediators of the immune cytokine action. The aim of this study was to test for associations between SOCS1 gene single nucleotide polymorphisms (SNPs) and the risk of developing acute coronary syndromes (ACS) in a group of Mexicans patients. Four SNPs [-3969 C > T (rs243327), -1656 G > A (rs243330), -820 G > T (rs33977706) and +1125 G > C (rs33932899)] of SOCS1 gene were determined for TaqMan genotyping assays in a group of 447 patients with ACS and 622 healthy controls. Under heterozygous model, the -3969 C > T (rs243327) SNP was associated with increased risk of ACS (OR = 1.45, P_Het = 0.021). On the other hand, under co-dominant and heterozygous models, the -1656 G/A (rs243330) SNP was associated with increased risk of ACS (OR = 1.47, P_Co-dom = 0.038 and OR = 1.50, P_Het = 0.013, respectively). Moreover, under co-dominant, dominant, and heterozygous models, the -820 T/G (rs33977706) SNP was associated with increased risk of ACS (OR = 1.59, P_Co-dom = 0.03, OR = 1.48, P_Dom = 0.028 and OR = 1.61, P_Het = 0.01). Finally, under co-dominant and heterozygous models, the +1125 G/C (rs33932899) SNP was associated with increased risk of ACS (OR = 1.54, P_Co-dom = 0.006, OR = 1.58, P_Het = 0.012, respectively). Models were adjusted for gender, age, body index mass, dyslipidemia, alcohol consumption, and smoking. In summary, our data suggests that the four studied polymorphisms of the SOCS1 gene play an important role as susceptibility markers for developing ACS.