Contributions of B cells to lupus pathogenesis |
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| Authors: | Allison Sang Ying-Yi ZhengLaurence Morel |
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| Affiliation: | Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA |
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| Abstract: | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells. |
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| Keywords: | Ab, antibody AFC, antibody forming cells BCR, B cell receptor DC, dendritic cell GC, germinal center IC, immune complex ICOS, inducible T cell co-stimulator PC, plasma cell SLE, systemic lupus erythematosus Tg, transgenic Ag, antigen MZ, marginal zone FO, follicle MZB cells, marginal zone B cells FOB cells, follicular B cells TC, triple congenic GN, Glomerulonephritis SNP, single nucleotide polymorphism PMN, polymorphonuclear neutrophil NET, neutrophil extracellular traps pDCs, plasmacytoid dendritic cells mDC, myeloid DC AID, activation induced (cytidine) deaminase MZMΦ, marginal zone macrophage AP, apoptotic cell DL1, delta-like 1 mAb, monoclonal antibody TFH, follicular helper T cells THEF, extrafollicular T cells SHM, somatic hypermutation |
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