丙型肝炎病毒感染的危险因素病例对照研究

目的:应用病例对照研究的方法分析丙型肝炎病毒感染的危险因素。方法:RT-PCR法定性测定HCV RNA,EIA法检测抗HCV。危险因素分析采用病例对照研究方法(病例数:对照数=1:4),用单因素分析筛选出危险因素,再应用多因素logistic回归分析确定危险因素。结果:单因素分析筛选出的危险因素有输血、静脉吸毒、纹身、流产、暴露性伤口缝合术、性伴有肝炎病史者、未用避孕套并性伴数多于1位者、社会经济贫困者、未婚怀孕者、与有丙肝病史的性伴共用生活用品者。多因素logistic回归分析确定的高危因素分别为输血、静脉吸毒、未用避孕套并性伴数多于1位。结论:输血、静脉吸毒、多于1个性伴而不用避孕套的性行为是丙型肝炎病毒感染的直接危险因素。

A Case-control Study on Risk Factors of Hepatitis C Virus Infection

Objective: To study on risk factors of hepatitis C virus infection in the native. Method: HCV RNA was assayed by RT-PCR. Antibody to HCV was detected by EIA. A case-control study was on risk factors of HCV infection. Risk factors were analyzed by the univariated analysis. Associated high risk factors were determined by multiple logistic regression analysis (Adjusted Odds Ratios >1, P<0.05). Results: The risk factors determined by the univariated analysis were transfusion, injection drug use, tattoos, abortions, sutured wounds, history of virus hepatitis in the sexual partner, more than 1 sexual partner and not use of condom, low socioeconomic status, unmarried pregnancy, sharing toiletries with a sexual partner with history of virus hepatitis. The risk factors determined by multiple logistic regression analysis were transfusion, injection drug use, more than 1 sexual partner and not use of condom, named high relative risk. Conclusion: Transfusion, injection drug use, sexual activity of more than 1 sexual partner and not use of condom were directly high risk factors of infected hepatitis C virus