| 用单抗标记SPA对甲型肝炎的诊断价值 |
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| 引用本文： | 岳启安,赵媛菊.用单抗标记SPA对甲型肝炎的诊断价值[J].潍坊医学院学报,1993,15(4):262-264. |
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| 作者姓名： | 岳启安 赵媛菊 |
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| 作者单位： | 潍坊医学院微生物学教研室，潍坊医学院微生物学教研室，潍坊医学院微生物学教研室，潍坊市人民医院儿科，中国预防医学科学院病毒所肝炎研究室，济南传染病院免疫室 |
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| 摘 要： | 利用甲型肝炎(甲肝)病毒特异的单克隆抗体标记 SPA 用于甲肝的早期诊断,结果与 ELISA 相比,其敏感性和特异性基本一致。29份 ELISA 阳性的甲肝血清,用甲肝病毒特异的单抗标记 SPA 作凝集试验,阳性率完全一致,而10份正常献血员和10份自身免疫病患者的血清,分别与 SPA 阳性诊断试剂和SPA 阴性对照试剂作凝集反应,均未出现明显凝集现象。此法简便,结果准确,特异性强,敏感性高,是一种理想的甲肝诊断试剂,并可作为粗筛的一种可靠手段。
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| 关 键 词： | 单克隆抗体 甲型肝炎 葡萄球菌蛋白 |
STUDY ON THE USE OF MCAb LABELED SPA FOR RAPID DIAGNOSIS OF HEPATITIS A |
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| Yue Qi'an.STUDY ON THE USE OF MCAb LABELED SPA FOR RAPID DIAGNOSIS OF HEPATITIS A[J].Journal of Weifang Medical College,1993,15(4):262-264. |
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| Authors: | Yue Qi'an |
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| Institution: | Yue Qi'an Department of Microbiology |
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| Abstract: | This stuy used specific hepatitis A McAb(monoclonal antibody)labeled SPA as reagent for early diagnosis of hepatitis A.Satisfactory results have been obtained with the reagent.The sensi- tivity and specificity of the test were similar basically as that of ELISA.The method was simple, accurate specific and with high sensitivity.It provided for clinic a ideal diagnostic reagent of hep- atitis A.It also might be used as a preliminary survey means for primary medical units.The false positive of the test has been overcome. |
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| Keywords: | monoclonal antibody staphylococcal protein A hepatitis A |
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