| 槟榔碱的中枢作用 |
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| 引用本文： | 邢淑华,姚兵,秦伟,卞春甫.槟榔碱的中枢作用[J].徐州医学院学报,1988(2). |
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| 作者姓名： | 邢淑华 姚兵 秦伟 卞春甫 |
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| 作者单位： | 徐州医学院药理学教研室
(邢淑华，姚兵，秦伟)，徐州医学院药理学教研室(卞春甫) |
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| 摘 要： | 给兔侧脑室注射槟榔碱出现抽搐、流涎、咀嚼,心率减慢,呼吸兴奋,但维持时间短暂。多数兔EEG呈双相反应,若与阿托品合用,脑电显示低幅快波并伴有痫样放电,而与东莨菪碱合用脑电则完全显示高幅慢波。提示槟榔碱可能为混合型的M胆碱受体激动剂。
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| 关 键 词： | 槟榔碱 药物作用 中枢神经系统 兔 |
CENTRAL EFFECTS OF ARECOLINE |
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| Xing shuhua,et al.CENTRAL EFFECTS OF ARECOLINE[J].Acta Academiae Medicinae Xuzhou,1988(2). |
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| Authors: | Xing shuhua |
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| Abstract: | Arecoline 0.1-0.4mg/kg icv to rabbits produced twitching, salivation and biphasic reaction in EEG ( initial low voltage rapid wave followed by high voltage slow wave 30 mm afterwards ) . Their respiration rate was increased by 112-162% in a linear- dose-effect fashion ( p<0.05-0.01 ) , which lasted for only 20 min before approximating to normal level. Combined use of atropine (0.05 mg/kg icv ) with arecoline caused epileptoid firing in EEG, while the addition of scopolamine (5.0 mg/kg, icv ) resulted in high voltage slow wave invariably. Arecoline 0.1-0.4mg/kg icv to rabbits caused bradycardia (p<0.05). The above results suggest : perhaps arecoline selectively acts on both excitatory M and inhibitory M2 receptors. |
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| Keywords: | arecoline drug effects central nervous system rabbits |
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