| 非霍奇金淋巴瘤的CD20分子显像及靶向治疗研究进展 |
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| 引用本文： | 查林,冯世斌,李前伟.非霍奇金淋巴瘤的CD20分子显像及靶向治疗研究进展[J].国际放射医学核医学杂志,2010,34(5). |
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| 作者姓名： | 查林 冯世斌 李前伟 |
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| 作者单位： | 重庆第三军医大学西南医院核医学科,400038 |
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| 摘 要： | 应用放射性核素标记B淋巴细胞分化抗原CD20单抗或其重组片段,在分子水平实现对非霍奇金淋巴瘤(NHL)显像和治疗,这将成为提高患者生存率的有效手段.该文介绍了CD20表面抗原的生物学特性及NHL抗CD20单抗的免疫治疗、放射免疫治疗以及放射免疫显像的研究进展.
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| 关 键 词： | 非霍奇金淋巴瘤 CD20 利妥昔单抗 免疫治疗 放射免疫显像 |
Progress of study on the molecular imaging and targeted therapy in CD20 of non Hodgkin' s lymphoma |
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| ZHA Lin,FENG Shi-bin,LI Qian-wei.Progress of study on the molecular imaging and targeted therapy in CD20 of non Hodgkin' s lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(5). |
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| Authors: | ZHA Lin FENG Shi-bin LI Qian-wei |
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| Abstract: | The molecular imaging and targeted therapy with radiolabeled anti-CD20 monoclonal antibody or recombinant anti-CD20 monoclonal antibody fragments is the effective methods to improve the survival rate for non-Hodgkin' s lymphoma (NHL). This article reviews the biological characteristics of CD20 and the immunotherapy, radioimmunotherapy, radioimmunoimaging with anti-CD20 monoclonal antibody for NHL. |
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| Keywords: | Non-Hodgkin' s lymphoma Cluster of differentiation 20 Rituximab Immunotherapy Radioimmunoimaging |
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