甲状腺癌骨转移模型的研究

甲状腺癌是内分泌系统最常见的恶性肿瘤,其发病率逐年上升,虽然该病预后较好,但若发生骨转移,患者10年生存率将明显降低。目前,甲状腺癌发生骨转移的机制尚不明确,对甲状腺癌骨转移的研究不仅具有重要的临床价值,也有很重要的科研价值。甲状腺癌骨转移动物模型的建立是研究甲状腺癌骨转移机制和治疗的基础,根据其建立方法可分为自发性、化学诱导性、转基因诱导性和移植性4种。

Research progress of animal model of bone metastases of thyroid carcinoma

Thyroid carcinoma is the most common endocrine malignancy, its incidence rate increases year by year. Although the disease has good prognosis, if bone metastases happen, 10-year survival rate of patients will obviously reduce. At present, the mechanism of the occurrence of bone metastases is not clear.The research of bone metastases of thyroid carcinoma not only has important clinical value, but also scientific value. Animal model of bone metastasis of thyroid carcinoma is the basis to study the mechanism and therapy of thyroid carcinoma. According to its establishment methods, it can be divided into four types, including spontaneous type, chemical induced type, transgenic induced type and transplanted type.