IL-8在乳腺癌组织中的表达及其临床意义

目的:检测乳腺癌组织中IL-8表达,探讨其与临床病理学因子及生物学因子的关系.方法:采用免疫组化SP法检测乳腺癌组织中IL-8、ER、PR、VEGF、MVD表达.结果:1)103例乳腺癌组织中IL-8( )表达率为34%、( )为35%、( )为10.7%,与正常及良性组织相比有显著性差异(P=0);2)IL-8表达水平与VEGF、MVD表达呈正相关(P=0);3)IL-8表达与淋巴结转移状况、组织学分级、临床分期有关(P＜0.05);4)IL-8与乳腺癌预后有关(P＜0.05);5)IL-8与ER、PR、肿瘤大小及病理类型无关(P＞0.05).结论:IL-8的表达水平与影响乳腺癌患者预后的生物学因素相关,IL-8高表达,预后差,可作为判断乳腺癌预后的指标.

The Expression and Significance of IL-8 in the Tissue of Breast Carcinoma

Objective: To study the expression of IL-8 in breast cancer and to explore the correlation between the expression of IL-8 and the characters of clinical pathology and biology. Methods: Immunohistochemistry was used to measure the expression of IL-8, ER, PR, VEGF and CD105 in breast carcinoma. Results: a. In 103 patients with breast cancer, the rate of IL-8 (+) was 34%, (++) was 35%, (+++) was 10.7%. The positive expression was significantly higher than in the normal and benign tissues (P=0). b. The expressions of IL-8 was correlated positively with the VEGF, CD105 (P=0). c. The expression of IL-8 was associated with the axillary lymph node, the different histological grade, the clinical stage (P<0.05). d. The expression of IL-8 was associated with prognosis of breast cancer (P<0.05). e. The expression of IL-8 was not related to ER, PR, the tumor diameter and the pathology type (P>0.05). Conclusions: The expression of IL-8 in breast carcinoma has a close relationship with prognosis factors, and can be used as an index for predicting the Prognosis.