Detecting protein losing enteropathy by Tc-99m dextran scintigraphy: a novel experience |
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Authors: | Kapoor Seema Ratan Simmi K Kashyap Ravi Mittal S K Rajeshwari K Rawat H Verma Jyoti |
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Affiliation: | Department of Pediatrics, MAMC and allied LN Hospital, New Delhi. seemam@vsnl.com |
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Abstract: | OBJECTIVE: To evaluate protien using enteropathy by Tc-99m dextran scintigraphy. METHODS: Methods for detecting protein loss from the intestine revolve around fecal nitrogen excretion, the clearance of alpha-1 antitrypsin in stools and by endoscopic biopsy. RESULT: The diagnosis of protein-losing enteropathy (PLE) can also be established by a scintigraphic method that is noninvasive, simple and requires no patient preparation or motivation. This diagnostic modality can also delineate the site of protein loss, thereby offering a targeted approach, and if need be, surgery. Radiolabelling of a non-protein, noncolloidal, nonparticulate and biofriendly molecule like dextran with Technetium-99m for imaging enteric protein loss was utilized in imaging eight children with PLE. CONCLUSION: The results were encouraging. The authors advocate the use of this diagnostic tool in identifying patients with PLE, particularly in the pediatric age group. |
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Keywords: | Tc-99m dextran Protein losing enteropathy |
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