Incidence and management of mycobacterial infection in solid organ transplant recipients |
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Authors: | Ming-Hui Fan Denis Hadjiliadis |
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Institution: | (1) Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, 835 West Gates Building, 3600 Spruce Street, Philadelphia, PA 19104, USA |
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Abstract: | Although advances in surgical technique, immunosuppressive regimens, and medical management have led to improved survival
and quality of life after solid organ transplantation, infection continues to represent a major cause of morbidity and mortality
in transplant recipients. Immunosuppressive therapy after transplantation compromises cell-mediated immunity in particular,
leaving the patient at risk for opportunistic as well as routine community-acquired infections. Mycobacterial infection is
a rare but important complication of solid organ transplantation, presenting significant risk to the patient and challenges
in terms of treatment. The available literature consists predominantly of case reports and institutional experiences. This
article examines both Mycobacterium tuberculosis and nontuberculous mycobacterial infection in the transplant setting. |
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Keywords: | |
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