泰利霉素侧链的合成 |
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引用本文: | 曹志凌,邹钰钰,陶传洲,宋晓凯.泰利霉素侧链的合成[J].中国医药工业杂志,2009,40(12). |
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作者姓名: | 曹志凌 邹钰钰 陶传洲 宋晓凯 |
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作者单位: | 1. 淮海工学院化学工程学院;江苏省海洋资源开发研究院,江苏连云港,222005 2. 淮海工学院化学工程学院 |
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摘 要: | 3-溴乙酰基吡啶经氨解、甲酰化、环合反应制得4-(3-吡啶基)-1H-咪唑,进而与N-(4-溴丁基)邻苯二甲酰亚胺缩合后肼解,制得泰利霉素侧链化合物4-4-(3-吡啶基)-1H-咪唑-1-基]-1-丁胺,总收率为33%.
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关 键 词: | 4-[4-(3-吡啶基)-1H-咪唑-1-基]-1-丁胺 泰利霉素 中间体 合成 |
Synthesis of Side Chain of Telithromycin |
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Authors: | CAO Zhi-ling ZOU Yu-yu TAO Chuan-zhou SONG Xiao-kai |
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Abstract: | 4-4-(3-Pyridinyl)-1H-imidazol-1-y1]-1-butanamine,the side chain of telithromycin,was synthesized from 3-(bromoacetyl)pyridine by aminolysis,formylation and cyclization to give 4-(3-pyridyl)-1H-imidazole,followed by condensation with N-(4-bromobutyl)phthalimide and hydrazinolysis with an overall yield of 33%. |
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Keywords: | 4-[4-(3-pyridinyl)-1H-imidazol-1-y1]-1-butanamine telithromycin intermediate synthesis |
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