Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone

Authors:	Akira Matsumoto

Affiliation:	(1) Department of Dental Pharmacology, School of Dentistry, Hokkaido University, Kita 13, Nishi 7, 060 Sapporo, Japan

Abstract:	We examined whether the bone resorption induced by PGE₂ was inhibited by SrCl₂ using⁴⁵Ca-labelled calvaria of CD-strain mice in tissue culture. It was found that Sr salts inhibited physiological bone resorption in a dose-dependent manner (0.1–5.0 mM) and did not act via PGE₂. Accordingly, it was suggested that Sr salts did not inhibit bone resorption induced by exogenous PGE₂.Abbreviations PGE₂ Prostaglandin E₂ - PTH Parathyroid hormone - CT Calcitonin - Vit. D₃ Vitamin D₃ - HSDM₁ Harvard School of Dental Medicine 1

Keywords:	Prostaglandin E₂ Strontium chloride Bone resorption ⁴⁵CaCl₂ Mouse calvaria
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