护肝片提高肝移植受者他克莫司血药浓度临床观察 |
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引用本文: | 张庆,陈虹,张力,牛玉坚,李莉,毛沙,王莹,李华,沈中阳. 护肝片提高肝移植受者他克莫司血药浓度临床观察[J]. 中国医院用药评价与分析, 2008, 8(7): 533-535 |
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作者姓名: | 张庆 陈虹 张力 牛玉坚 李莉 毛沙 王莹 李华 沈中阳 |
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作者单位: | 张庆 (武警总医院肝移植研究所,北京市,100039); 陈虹 (武警总医院肝移植研究所,北京市,100039); 张力 (武警陕西总队医院外一科,西安市,710054); 牛玉坚 (武警总医院肝移植研究所,北京市,100039); 李莉 (武警总医院肝移植研究所,北京市,100039); 毛沙 (武警总医院肝移植研究所,北京市,100039); 王莹 (武警总医院肝移植研究所,北京市,100039); 李华 (武警总医院口腔科,北京市,100039); 沈中阳 (武警总医院肝移植研究所,北京市,100039); |
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摘 要: | 目的:评价应用护肝片提高肝移植受者全血他克莫司(FK506)药物浓度的疗效。方法:将56例肝移植术后长期服用FK506的受者作为研究对象,FK506和护肝片同时服用的受者为试验组(27例),单纯口服FK506的受者为对照组(29例);检测两组全血FK506浓度及肝、肾功能,作为临床评价指标。结果:试验组服药后FK506血药浓度比服药前分别增加了2.718±0.45ng·mL^-1,增幅达60.35%,两者比较有显著性差异(P〈0.01);与对照组比较亦有显著性差异(P〈0.01)。停用护肝片后,全血FK506浓度明显降低,降幅达32.30%,差异有显著性(P〈0.01)。FK506和护肝片合用对肝、肾功能指标无明显不良影响。结论:护肝片能明显提高他克莫司药物浓度。
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关 键 词: | 药物检测 肝移植 他克莫司 护肝片 |
Effect of Liver - aid Tablet on Bloods Concentration of Tacrolimus in Patients Undergoing Liver Transplantation |
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Affiliation: | ZHANG Qing , CHEN Hong, ZHANG Li, NIU Yu-jian, LI Li, MAO Sha, WANG Ying, LI Hua, SHEN Zhong-yang ( 1. Institute of Liver Transplantation, General Hospital of Chinese People' s Armed Police Forces, Beijing 100039, China; 2. First Surgery Dept., Shannxi General Hospital of Chinese People' s Armed Police Forces, Xi'an 710054, China; 3. Dept. of Stomatology, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China) |
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Abstract: | OBJECTIVE: To evaluate the efficacy of Liver-aid tablet in increasing tacrolimus (FK506)concentration in patients undergoing liver transplantation. METHODS: A total of 56 patients undergoing liver transplantation treated with FK506 were enrolled: 27 were assigned to receive FK506 plus Liver-aid tablet (experimental group), and 29 to receive FK506 alone (control group). Blood concentrations of FK506, and biochemistry indexes for liver and renal function were determined. RESULTS: After medication, the blood concentrations of FK506 in the experimental group increased 2.718 ±0.451ng·mL^-1(up 60.35 % ), showing significant differences as compared with before medication (P 〈 0.01), and the difference was also significant as compared with control group ( P 〈 0.01 ). However, after withdrawal of the Liver - aid tablet, the blood concentrations of FK506 were significantly decreased, down 32.30 %, and the difference was significant ( P 〈 0.01). Used in combination, FK506 and Liver - aid tablet had no significant effects on the indexes of liver or liver function. CONCLUSION: Liver- aid tablet could markedly elevate the blood concentration of FK506 in patients undergoing liver transplantation. |
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Keywords: | Drug monitoring Liver transplantation Tacrolimus tablet Liver- aid tablet |
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