The AGTR1 gene A1166C polymorphism as a risk factor and outcome predictor of primary intracerebral and aneurysmal subarachnoid hemorrhages |
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| Affiliation: | 1. Department of Neurology, Jagiellonian University Medical College, Krakow, Poland;2. Department of Neurology, SUNY Downstate Medical Center, Brooklyn, USA;3. Department of Neurosurgery and Neurotraumatology, Jagiellonian University Medical College, Krakow, Poland;1. 2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa, Poland;2. Chair and Department of General, Transplant and Liver Surgery, Medical University of Warsaw, ul. Banacha 1A, 02-097 Warszawa, Poland;3. Department of Toxicology, Medical University of Warsaw, Faculty of Pharmacy, ul. Banacha 1, 02-097 Warsaw, Poland;1. Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany;2. CRS Clinical Research Services Mannheim GmbH, Grenadierstrasse 1, 68167 Mannheim, Germany;1. Department of Neurology, Jagiellonian University Medical College, Krakow, Poland;2. Department of Neurology, Medical University of Silesia, Katowice, Poland;3. Department of Neurology, St. Adalbert Hospital, Gdansk, Poland;4. Department of Neurological and Psychiatric Nursing, Medical University of Gdansk, Gdańsk, Poland;1. Department of Gynecology and Oncology, Jagiellonian University, Krakow, Poland;2. Department of Pathomorphology, Jagiellonian University, Krakow, Poland;3. Ludwin and Ludwin Gynecology, Krakow, Poland;1. University of Bremen, UFT, General and Theoretical Ecology, Leobener Str., D-28359 Bremen, Germany;2. Centre for Environmental Research Leipzig-Halle, Theodor-Lieser-Str. 4, 06120 Halle, Germany |
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| Abstract: | Associations between the angiotensin II type 1 receptor (AGTR1) gene A1166C polymorphism and hypertension, aortic abdominal aneurysms (as a risk factor) as well as cardiovascular disorders (as a risk factor and an outcome predictor) have been demonstrated. We aimed to investigate the role of this polymorphism as risk factors and outcome predictors in primary intracerebral hemorrhage (PICH) and aneurysmal subarachnoid hemorrhage (aSAH).We have prospectively recruited 1078 Polish participants to the study: 261 PICH patients, 392 aSAH patients, and 425 unrelated control subjects. The A1166C AGTR1 gene polymorphism was studied using the tetra-primer ARMS-PCR method. Allele and genotype frequencies were compared with other ethnically different populations.The A1166C polymorphism was not associated with the risk of PICH or aSAH. Among the aSAH patients the AA genotype was associated with a good outcome, defined by a Glasgow Outcome Scale of 4 or 5 (p < 0.02). The distribution of A1166C genotypes in our cohort did not differ from other white or other populations of European descent.In conclusion, we found an association between the A1166C AGTR1 polymorphism and outcome of aSAH patients, but not with the risk of PICH or aSAH. |
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| Keywords: | Intracerebral hemorrhage Aneurysmal subarachnoid hemorrhage Outcome Stroke |
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