Circle of Willis abnormalities in children with neurofibromatosis type 1 |
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| Affiliation: | 1. Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA;2. Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri, USA;1. Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio;2. Center for Neuroimaging, Neurological Institute, Cleveland Clinic, Cleveland, Ohio;1. Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri;2. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;3. Department of Neurology, Washington University School of Medicine, St. Louis, Missouri;1. 2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland;2. Interventional Stroke Treatment Centre, Institute of Psychiatry and Neurology, Warsaw, Poland;3. Department of Neurology and Stroke Unit, Holy Spirit Specialist Hospital in Sandomierz, Sandomierz, Poland;4. Department of Neurology, University Hospital no. 2, Bydgoszcz, Poland;5. Department of Neurology A, Provincial Specialistic Team Neuropsychiatric, Opole, Poland;6. Department of Neurology, Pomeranian Trauma Centre, Gdańsk, Poland;7. Department of Neurology, Medical University of Gdańsk, Gdańsk, Poland;8. Department of Neurology, Voivodship Hospital no. 2, Rzeszów, Poland;9. Department of Neurology, Central Clinical Hospital of the Ministry of the Interior, Warsaw, Poland;1. Scientific and Technological Research Application and Research Center, Sinop University, 57010 Sinop, Turkey;2. Deparment of Chemistry, Faculty of Arts and Sciences, Recep Tayyip Erdoğan University, 53150 Rize, Turkey;3. Vocational School of Health Services, Karadeniz Technical University, 61080 Trabzon, Turkey;4. Department of Physics, Faculty of Arts and Sciences, Ondokuz Mayıs University, 55139 Samsun, Turkey;1. Department of Neurosurgery, Postgraduate Medical Center, Warsaw, Poland;2. Department of Neurological-Psychiatric Nursing and Department of Neurology, Medical University of Gdansk and St. Adalbert Hospital, Gdansk, Poland |
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| Abstract: | Background and purposeThe aim of the study was to assess anatomical variants and abnormalities in cerebral arteries on magnetic resonance angiography in 67 children with neurofibromatosis type 1 (NF1).Materials and methodsThe study included 67 children aged 9 months to 18 years (mean 6.6 years). Control group comprised 90 children aged 2–18 years (mean: 11.8 years). All patients were examined at 1.5 T scanner.ResultsWe found cerebral arteriopathy (moyamoya disease) in one child (1.5%) in the study group. No aneurysms were found. Twenty-nine NF1 children (43.3%) had arterial anatomical variants. In 13 of them, more than one variant was diagnosed (44.8% of group with variants, 19.4% of study group). In control group, 19 children (21.1%) had variants, including four children with more than one variant (21% of group with variants, 4.4% of control group). Arterial variants were more common in NF1 patients compared with control group (p = 0.026, binomial test for two proportions). Percentage of multiple variants was higher in study group than in control group, but this difference was not significant. Variants were more frequent on left side than on the right one (significant difference in control group; p = 0.022, McNemara test). In study group, the number of left-sided anomalies (25) was similar to that of right-sided ones (22). There was no correlation between gender and variants, unidentified bright objects and variants or between optic gliomas and variants.ConclusionsOccurrence of arterial variants in NF1 patients was twofold higher than in control group. Multiple variants were more frequent in the study group although the difference did not reach statistical significance. Features of cerebral arteriopathy were found in one child with NF1. |
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| Keywords: | Neurofibromatosis type 1 Magnetic resonance angiography Brain Arteriopathy Arterial variants |
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