Preptin对2型糖尿病性骨质疏松患者骨密度的相关性

目的 探讨Preptin在2型糖尿病性骨质疏松患者骨密度（bone mineral density，BMD）的相关性。方法 纳入2型糖尿病患者88例，根据骨密度T值分为3组：骨量正常组（T值＞-1.0）(N组）、骨量减少组(-2.5＜T值≤-1.0)（R组）和骨质疏松组（T值≤-2.5）（OP组），比较3组患者一般临床资料、临床检验指标、骨密度、血浆Preptin以及结缔组织生长因子（connective tissue growth factor，CTGF）、骨特异性碱性磷酸酶（bone specific alkaline phosphatase，BAP）水平，利用Pearson相关分析研究BMD与一般资料、临床检验资料及骨代谢相关指标间的相关性，并采用SPSS 19.0统计学软件进行Preptin与CTGF、BAP相关曲线的绘制。结果 3组患者体重、体质量指数差异有统计学意义（P＜0.05）。3组患者骨密度以及骨代谢相关指标均存在显著差异，随着骨密度的降低，3组间Preptin、CTGF、BAP浓度逐渐降低，差异均有统计学意义（P＜0.05）。L2～L4 BMD与Preptin、ALP-B、CTGF均呈正相关，Preptin与ALP-B、CTGF均呈正相关(P＜0.05)。结论 Preptin通过调节CTGF、BAP水平，在2型糖尿病性骨质疏松症的发生发展中发挥重要作用。

The correlation between Preptin and bone mineral density in patients with osteoporosis and type 2 diabetes

Objective To investigate the correlation between Preptin and bone mineral density (BMD) in type 2 diabetes induced osteoporosis. Methods Eighty-eight patients with type 2 diabetes were included. They were divided into three groups according to T value of BMD: normal bone mass group (T-value greater than -1.0, N group), osteopenia group (T-value less than -1.0 and greater than -2.5, R group), and osteoporosis group (T-value less than -2.5, OP group). The general clinical data, clinical laboratory data, BMD, plasma leptin, connective tissue growth factor (CTGF), and bone specific alkaline phosphatase (BAP) levels among the three groups were compared. Pearson correlation analysis was used to study the correlation between BMD and general data, clinical laboratory data, and bone metabolism related indicators. SPSS 19.0 statistical software was used to draw the correlation curve between leptin, CTGF, and BAP. Results There were significant differences in weight and BMI among the three groups (P<0.05). There were significant differences in BMD and bone metabolism related indexes among the three groups. With the decrease of BMD, the levels of leptin, CTGF, and BAP among the three groups decreased gradually, with significant differences (P<0.05). BMD of L2-L4 was positively correlated with Preptin, ALP-B, and CTGF, and Preptin was positively correlated with ALP-B and CTGF (P<0.05). Conclusion Preptin plays an important role in the occurrence and development of type 2 diabetes induced osteoporosis by regulating the levels of CTGF and BAP. Preptin is expected to become a new target for the treatment of type 2 diabetes induced osteoporosis.