| 骨源性外泌体microRNAs与骨质疏松症相关研究进展 |
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| 引用本文： | 谢兴文 闫文顾玉彪,李鼎鹏于文霞 马成李文广,高亚雄. 骨源性外泌体microRNAs与骨质疏松症相关研究进展[J]. 中国骨质疏松杂志, 2023, 0(5): 687-690 |
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| 作者姓名： | 谢兴文 闫文顾玉彪 李鼎鹏于文霞 马成李文广 高亚雄 |
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| 作者单位： | 1.甘肃中医药大学附属医院,甘肃 兰州 7300002.甘肃中医药大学,甘肃 兰州 7300003.甘肃省中医院,甘肃 兰州 7300004.甘肃省第二人民医院,甘肃 兰州 730000 |
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| 基金项目： | 国家自然科学基金（82160911）;甘肃省拔尖领军人才项目;甘肃省科技计划资助（20JR5RA129）;兰州市人才创新创业项目（2021-RC-131）;甘肃省中医药研究中心开放课题（zyzx-2020-32）;中央高校基本科研业务费项目（31920210041） |
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| 摘 要： | 骨质疏松症作为老年疾病中的一种代谢性疾病,对它的研究一直被认为是重点和难点,因此如何延缓骨质疏松症的进展成为最主要的问题。骨源性外泌体microRNAs作为骨科疾病的关键调节因子,其表达的变化对延缓骨质疏松症的进展具有调节作用。microRNAs通过调节相关因子的表达可延缓骨质疏松症的发生及进展。该文就骨源性外泌体microRNAs与骨质疏松症的相关性进行综述,以期为骨源性外泌体microRNAs在治疗骨质疏松症方面提供一些新的治疗思路。
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| 关 键 词： | 骨源性外泌体 microRNAs 骨质疏松 成骨细胞 破骨细胞 |
Progress in the research of the correlation between osteogenic exosomal microRNAs and osteoporosis |
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| XIE Xingwen,YAN Wen,GU Yubiao,LI Dingpeng,YU Wenxi,MA Cheng,LI Wenguang,GAO Yaxiong. Progress in the research of the correlation between osteogenic exosomal microRNAs and osteoporosis[J]. Chinese Journal of Osteoporosis, 2023, 0(5): 687-690 |
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| Authors: | XIE Xingwen YAN Wen GU Yubiao LI Dingpeng YU Wenxi MA Cheng LI Wenguang GAO Yaxiong |
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| Affiliation: | 1.Gansu University of Traditional Chinese Medicine, Lanzhou 7300002.The Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 7300003.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 7300004.The Second People''s Hospital of Gansu Province, Lanzhou 730000, China |
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| Abstract: | Osteoporosis as a metabolic disease among the diseases of the elderly has always been regarded as a key and difficult point to study. How to delay the progression of osteoporosis has become the most important issue. MicroRNAs are key regulators of orthopedic diseases. The changes in their expression have a regulatory effect on delaying the progression of osteoporosis. Bone-derived exosomal microRNAs may delay the occurrence and progression of osteoporosis by regulating the expression of related factors. This article reviews the correlation between bone-derived exosomal microRNAs and osteoporosis, in order to provide some new therapeutic ideas for bone-derived exosomal microRNAs in the treatment of osteoporosis. |
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| Keywords: | bone-derived exosomal microRNAs osteoporosis osteoblasts osteoclasts |
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