中药干预骨髓间充质干细胞成骨分化治疗非创伤性股骨头坏死研究进展

非创伤性股骨头坏死（nontraumatic osteonecrosis of the femoral head,NONFH）作为一种骨结构和生物力学的发生改变可导致髋关节功能丧失的一种难治性骨关节病,主要可分为糖皮质激素性和酒精性两大类。骨髓间充质干细胞（bone marrow mesenchymal stem cells,BMSCs）作为保持骨稳态的主要干细胞,具有分化为成骨细胞、软骨细胞的能力。通过调控BMSCs向成骨细胞、软骨细胞分化对NONFH的进行修复和重建意义重大。中药在中医学“整体观念、辨证论治”理论指导下防治“骨蚀、骨痹”历史悠久、疗效显著。中药通过促进BMSCs向成骨细胞、软骨细胞分化,避免其向脂肪细胞分化,对NONFH的治疗有着重要意义。基于此,该文将中药调控BMSCs分化功能治疗NONFH最新研究进展进行综述,旨为NONFH相关研究的深入及临床防治提供思路和参考。

Research progress of intervention with traditional Chinese medicine in osteogenic differentiation by bone marrow mesenchymal stem cells in the treatment of non-traumatic femoral head necrosis

Non-traumatic osteonecrosis of the femoral head (NONFH) is a kind of refractory osteoarthropathy that changes in bone structure and biomechanics, leading to the loss of hip function. It can be divided into two categories: glucocorticoid and alcohol. Bone marrow mesenchymal stem cells (BMSCs), as the main stem cells to maintain bone homeostasis, have the ability to differentiate into osteoblasts and chondrocytes. It is of great significance to repair and reconstruct NONFH by regulating the differentiation of BMSCs into osteoblasts and chondrocytes. Traditional Chinese medicine has a long history in the treatment of bone erosion and bone impediment under the guidance of overall concept and syndrome differentiation. Traditional Chinese medicine is of great significance in the treatment of NONFH by promoting the differentiation of BMSCs into osteoblasts and chondrocytes and avoiding their differentiation into adipocytes. Based on this, this article reviews the latest research progress of traditional Chinese medicine in regulating the differentiation function of BMSCs in the treatment of NONFH, aiming to provide ideas and references for the in-depth research and clinical prevention and treatment of NONFH.