Peroxiredoxin isoforms are associated with cardiovascular risk factors in
type 2 diabetes mellitus |
| |
Authors: | E El Eter AA Al-Masri |
| |
Institution: | 1.Physiology Department, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia;2.Cardiovascular Research Group, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia;3.Physiology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt |
| |
Abstract: | The production of oxygen free radicals in type 2 diabetes mellitus contributes to the
development of complications, especially the cardiovascular-related ones.
Peroxiredoxins (PRDXs) are antioxidant enzymes that combat oxidative stress. The aim
of this study was to investigate the associations between the levels of PRDX isoforms
(1, 2, 4, and 6) and cardiovascular risk factors in type 2 diabetes mellitus.
Fifty-three patients with type 2 diabetes mellitus (28F/25M) and 25 healthy control
subjects (7F/18M) were enrolled. We measured the plasma levels of each PRDX isoform
and analyzed their correlations with cardiovascular risk factors. The plasma PRDX1,
-2, -4, and -6 levels were higher in the diabetic patients than in the healthy
control subjects. PRDX2 and -6 levels were negatively correlated with diastolic blood
pressure, fasting blood sugar, and hemoglobin A1c. In contrast, PRDX1 levels were
positively correlated with low-density lipoprotein and C-reactive protein levels.
PRDX4 levels were negatively correlated with triglycerides. In conclusion, PRDX1, -2,
-4, and -6 showed differential correlations with a variety of traditional
cardiovascular risk factors. These results should encourage further research into the
crosstalk between PRDX isoforms and cardiovascular risk factors. |
| |
Keywords: | Peroxiredoxins Type 2 diabetes mellitus Oxidative stress Cardiovascular risk factors |
|
|