The role of pleiotrophin in bone repair |
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| Institution: | 1. Laboratory of Molecular Pharmacology, Department of Pharmacy, School of Health Sciences, University of Patras, 26504 Patras, Greece;2. Academic Department of Trauma & Orthopaedics, School of Medicine, University of Patras, Greece;3. Academic Department of Trauma & Orthopaedic Surgery, University of Leeds, Clarendon Wing, Floor A, Great George Street, Leeds General Infirmary, LS1 3EX Leeds, UK;4. NIHR Leeds Biomedical Research Unit, Chapel Allerton Hospital, LS7 4SA Leeds, West Yorkshire, UK;1. Department of Orthopaedics, Chinese PLA General Hospital, No. 28 Fuxin Road, Beijing 100853, PR China;2. Medical College, Nankai University, No. 94 Weijin Road, Tianjin 300071, PR China;1. Leicester Royal Infirmary, Leicester, UK;2. University Hospitals of North Tees, Stockton-On-Tees, UK;3. Northampton General Hospital, Northampton, UK;4. University Hospitals of Coventry and Warwickshire, UK;5. Harcourt Building, 8 Harcourt Crescent, Sheffield, UK;1. North West Deanery, Manchester, England, United Kingdom;2. Royal Blackburn Hospital, Lancashire, England, United Kingdom |
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| Abstract: | Bone has an enormous capacity for growth, regeneration, and remodelling, largely due to induction of osteoblasts that are recruited to the site of bone formation. Although the pathways involved have not been fully elucidated, it is well accepted that the immediate environment of the cells is likely to play a role via cell–matrix interactions, mediated by several growth factors. Formation of new blood vessels is also significant and interdependent to bone formation, suggesting that enhancement of angiogenesis could be beneficial during the process of bone repair. Pleiotrophin (PTN), also called osteoblast-specific factor 1, is a heparin-binding angiogenic growth factor, with a well-defined and significant role in both physiological and pathological angiogenesis. In this review we summarise the existing evidence on the role of PTN in bone repair. |
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| Keywords: | Angiogenesis Bone Bone repair Osteoblasts Osteoclasts Pleiotrophin |
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