Association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension: A systematic review and meta-analysis |
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| Affiliation: | 1. Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China;2. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No. 81 MeiShan Road, Hefei 230032, Anhui, China;3. Centre for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China;1. Division of Weight Management and Wellness, Metabolism and Diabetes Mellitus, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201;2. Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201;3. Physical Education and Sports Science Academic Group, Nanyang Technological University, Singapore 637616;4. Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX;5. Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon;6. Departments of Pediatrics, Indiana University School of Medicine, Indianapolis, IN;1. Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX;2. Department of Surgery, University of Texas Medical Branch, Galveston, TX;3. Shriners Hospitals for Children, Galveston, TX;4. Sulpizio Cardiovascular Center, University of California, San Diego, CA;5. University of Arkansas for Medical Sciences, Little Rock, AR;1. Laboratory of Medical Investigation 18 - LIM-18, Endocrinology Division, Medical School, University of São Paulo, SP, Brazil;2. Bone Metabolism Laboratory, Rheumatology Division, Medical School, University of São Paulo, SP, Brazil;1. Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA;2. Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL 60612, USA |
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| Abstract: | ObjectiveMany studies have investigated the role of 5,10-methylenetetrahydrofolate reductase gene (MTHFR) C677T/A1298C polymorphisms in essential hypertension (EH), but results are inconclusive. The purpose of this meta-analysis was to clarify the effects of MTHFR C677T/A1298C polymorphisms on the risk of EH.MethodsElectronic databases were searched to identify relevant studies published until January 2014. Data were extracted by two independent authors. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR C677T/A1298C polymorphisms and the risk of EH using random effect models or fixed effect models. Finally, 30 studies with 5207 cases and 5383 controls were included for C677T polymorphism and 6 studies with 1009 cases and 994 controls were included for A1298C polymorphism.ResultsMeta-analysis results indicated that MTHFR C677T polymorphism contributed to an increased risk of EH (for T vs. C: OR = 1.30, 95%CI = 1.18–1.43; for TT + CT vs. CC: OR = 1.34, 95%CI = 1.24–1.46; for TT vs. CC: OR = 1.62, 95%CI = 1.32–1.99; for TT vs. CT + CC: OR = 1.41, 95%CI = 1.26–1.59). However, no significant association was detected between MTHFR A1298C polymorphism and the risk of EH.ConclusionThis meta-analysis supports that MTHFR C677T polymorphism plays a role in developing EH. MTHFR A1298C polymorphism may not be associated with an increased risk of EH. Further large and well-designed studies are warranted to confirm these findings. |
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