Alternating hemiplegia of childhood: New diagnostic options |
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| Institution: | 1. Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan;2. Department of Physical Therapy, College of Life and Health Sciences, Chubu University, Kasugai, Japan;1. Department of Neurology, The University Hospital in Krakow, Krakow, Poland;2. Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece;3. Chair of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland;4. Department of Neurology, Jagiellonian University Medical College, Krakow, Poland;5. Department of Neurosurgery, University of Thessaly, University Hospital of Larissa, Larissa, Greece;1. Research Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK;1. Dept. of Neurology, Jagiellonian University Medical College, Cracow, Poland;2. Institute of Biomedical Engineering and Instrumentation, Wrocław University of Technology, Wrocław, Poland;3. Dept. of Mathematical Statistics, University of Agriculture, Cracow, Poland |
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| Abstract: | A syndrome of alternating hemiplegia of childhood (AHC) is a rare disorder first presented in 1971. AHC is characterized by transient episodes of hemiplegia affecting either one or both sides of the body. Age of onset is before 18 months and the common earliest manifestations are dystonic or tonic attacks and nystagmus. Hemiplegic episodes last minutes to days and the frequency and duration tend to decrease with time. Motor and intellectual development is affected, deficits may also develop later. Epileptic seizures occur in some patients. Neuroimaging of the brain usually reveals no abnormalities. The variability of individual clinical presentations and evolution of symptoms have made diagnosis difficult. Therefore the problems of misdiagnosis could account for the low prevalence of this syndrome. This paper hopes to present actual data on AHC, especially of the results of genetic research and new diagnostic tools. |
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| Keywords: | Alternating hemiplegia Children |
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