Serotonin transporter gene polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia |
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| Affiliation: | 1. Department of Psychiatry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latif, 56000, Cheras, Kuala Lumpur, Malaysia;2. Department of Biotechnology, Institute of Medical Research, Jalan Pahang, 505888, Kuala Lumpur, Malaysia;1. Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;2. Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;3. Department of Neurology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;4. Department of Pediatrics, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;5. Department of Endocrinology and Metabolism, Kin-i-kyo Chuo Hospital, Sapporo, Japan;1. JC School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China;2. Alice Lee Centre for Nursing Studies, National University of Singapore, Singapore;3. Hospital Authority Information Technology Services — Health Informatics Section, Hong Kong, China;4. Menzies Centre for Health Policy, University of Sydney, Australia |
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| Abstract: | ObjectivesThe risk variants have been shown to vary substantially across populations and a genetic study in a heterogeneous population might shed a new light in the disease mechanism. This preliminary study aims to determine the frequency of the serotonin transporter gene polymorphism (5-HTTLPR) in the three main ethnic groups in Malaysia and its association with bipolar disorder.MethodsThis is a candidate gene association study of randomly selected forty five unrelated bipolar disorder probands and sixty six controls. Diagnosis was evaluated using the Mini International Neuropsychiatric Interview (M.I.N.I). The control group consisted of healthy volunteers without personal psychiatric history and family history of mood disorder. Patients' whole blood was collected for genotyping.ResultsThis study revealed that the frequency of the short variant of 5-HTTLPR in healthy control group was highest in Indians (42.9%) followed by Malays (23.5%) and was absent in Chinese. The association between the homozygous ss genotype of the 5-HTTLPR polymorphism with bipolar disorder was not found in the pooled subjects (χ2 = 1.52, d.f. = 1, p = 0.218, OR = 4.67, 95% C.I. = 0.69–7.58) and after stratification into Malays (p = 0.315, OR = 2.03, 95% CI = 0.50–8.17), Indians (p = 0.310; OR = 0.44, 95% CI = 0.21–0.92) and Chinese.ConclusionThe differences in the frequency of the short allele of 5-HTTLPR across the three main ethnic groups in Malaysia were noteworthy. The present study showed no significant association between the homozygous short variant of the 5-HTTLPR and bipolar disorder in the pooled subject and after stratification into the three main ethnic groups in Malaysia. |
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