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无淋巴结转移的直肠癌nm23-H1、p21表达与预后的关系
引用本文:裴锋,张克亮,冯茂辉,王维娜. 无淋巴结转移的直肠癌nm23-H1、p21表达与预后的关系[J]. 临床外科杂志, 1999, 7(6): 341-342
作者姓名:裴锋  张克亮  冯茂辉  王维娜
作者单位:1. 430070,武汉,湖北省肿瘤医院外Ⅱ科
2. 同济医科大学同济医院
3. 黄石市卫校
摘    要:目的探讨无淋巴结转移的直肠癌中nm23-H1、p21表达与预后的关系。方法应用免疫组织化学方法观察84例无淋巴结转移的直肠腺癌nm23-H1、p21的表达。结果在生存期<5年的32例患者中,nm23-H1阴性表达着26例(81.3%),p21阳性表达者28例(87.5%),在生存期>5年的52例患者中,nm23-H1阴性表达者11例(21.2%),p21阳性表达着20例(38.5%),nm23-H1及p21在2组中表达差异有显著性(P<0.05)。结论无淋巴结转移的直肠癌中nm23-H1低表达及p2I阳性表达与5年生存率密切相关,这对术后综合治疗方案选择有指导作用。

关 键 词:直肠肿瘤  免疫组织化学
修稿时间::1999-08-1

The relation between expression of nm23-H1 and p21 in rectal adenocarcinomas without lymph node metastasis and the clinical prognosis
PEI Feng,FENG Maohui,WANG Weina,etalHubei Province Tumor Hospital,Wuhan. The relation between expression of nm23-H1 and p21 in rectal adenocarcinomas without lymph node metastasis and the clinical prognosis[J]. Journal of Clinical Surgery, 1999, 7(6): 341-342
Authors:PEI Feng  FENG Maohui  WANG Weina  etalHubei Province Tumor Hospital  Wuhan
Affiliation:PEI Feng,FENG Maohui,WANG Weina,etalHubei Province Tumor Hospital,Wuhan 430070
Abstract:Objectivc To study the expression of nm23-H1 and p21 gene in rectaladenocarcinomas without lymph node metastasis and its relation to the clinical prognosis. Method 84cases were subjected to immunhistochemica1 study to observe the expresion of nm23-Hl and p2l protein inadenocarcinomas. Result Among 32 cases with less than 5 years survival, the negative expression ofnm23-H1 in adnocarcinomas was revealed in 26 cases (81. 3%), the positive expression of p21 inadenocorcinoma was revealed in 28 cases (87. 5%). However, among 52 cases with more than 5 yearssurvial, the negative expression of nm23-H1 was ll cases (21.2% ), the positive expresstion of p21 was20 cases (38. 5% ). The difference between two group was prominent (P
Keywords:nm23-H1  p21
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