The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes |
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| Authors: | B. M. Shields T. J. McDonald S. Ellard M. J. Campbell C. Hyde A. T. Hattersley |
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| Affiliation: | (1) Peninsula NIHR Clinical Research Facility, Peninsula Medical School, University of Exeter, Barrack Road, Exeter, EX2 5DW, UK;(2) Royal Devon and Exeter NHS Foundation Trust, Exeter, UK;(3) School of Health and Related Research, University of Sheffield, Sheffield, UK;(4) Peninsula Technology Assessment Group, Peninsula Medical School, University of Exeter, Salmon Pool Lane, Exeter, UK; |
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| Abstract: | Aims/hypothesis Diagnosing MODY is difficult. To date, selection for molecular genetic testing for MODY has used discrete cut-offs of limited clinical characteristics with varying sensitivity and specificity. We aimed to use multiple, weighted, clinical criteria to determine an individual’s probability of having MODY, as a crucial tool for rational genetic testing. |
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