| 醋酸纤维／聚乙烯基亚胺膜去除血清胆红素同时对肝病相关因子影响的研究 |
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| 引用本文： | 李蕾蕾,段志军,鞠佳,贺高红,高志红,李晓宁.醋酸纤维／聚乙烯基亚胺膜去除血清胆红素同时对肝病相关因子影响的研究[J].中国血液净化,2008,7(12):641-643. |
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| 作者姓名： | 李蕾蕾 段志军 鞠佳 贺高红 高志红 李晓宁 |
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| 作者单位： | 1. 大连医科大学附属第一医院消化内科,大连,116011
2. 大连理工大学膜科学与技术研究中心,大连,116012 |
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| 基金项目： | 辽宁省教育厅资助项目
，
教育部留学回国人员科研启动基金
，
国家自然科学基金
，
辽宁省自然科学基金
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| 摘 要： | 目的探讨醋酸纤维素／聚乙烯基亚胺（CA／PEI）膜在吸附血清胆红素同时对慢性肝病患者部分细胞因子、免疫球蛋白、补体的影响。方法应用CA／PEI膜吸附30例黄疸患者血清，ELISA法测定吸附前后白细胞介素6（IL-6）、白细胞介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）和转化生长因子-β1（TGF-β1）含量，免疫散射比浊法测定免疫球蛋白-A（IgA）、免疫球蛋白-M（IgM）、免疫球蛋白-G（IgG），补体-3（C3）和补体-4（C4）含量。结果吸附后IL-6、TNF-α和TGF-β1下降（P〈0．05），IL-10无明显变化；免疫球蛋白和补体亦无变化。结论：CA／PEI膜在去黄同时可对肝病进展相关的一些血液成分有不同影响。
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| 关 键 词： | 亲和膜 细胞因子 免疫指标 |
Experimental study OR CA/PEI membrane to the factors relating to liver diseases along with the clearance of bilirubin |
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| LI Lei-lei,DUAN Zhi-jun,JU Jia,HE Gao-hong,GAO Zhi-hong,LI Xiao-ning.Experimental study OR CA/PEI membrane to the factors relating to liver diseases along with the clearance of bilirubin[J].Chinese Journal of Blood Purification,2008,7(12):641-643. |
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| Authors: | LI Lei-lei DUAN Zhi-jun JU Jia HE Gao-hong GAO Zhi-hong LI Xiao-ning |
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| Institution: | LI Lei-lei,DUAN Zhi-jun,JU Jia,HE Gao-hong,GAO Zhi-hong,LI Xiao-ning.(1.Gastroenterology Dept., First Affiliated Hospital of Dalian Medical University, Dalian 116011; 2.Membrane Science and Technology Center, Dalian University of Technology, Dalian 116011,China) |
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| Abstract: | Objective To study the effect of CA/PEI membrane on cytokines, immunoglubin and complements along with bilirubin clearance in chronic liver diseases. Methods We used CA/PEI membrane to adsorb jaundice sera from 30 cases for 2 hours. Serum IL-6, IL-10, TNF-α and TGF-β1 were measured by ELISA before and after the adsorption. IgA, IgM, IgG, C3 and C4 were detected by immune scatter turbidimetry. Results After the adsorption, serum IL-6, TNF-α and TGF-β1 decreased （P〈0.05）, and IL-10, immunoglobulin and complements remained unchanged. Conclusion CA/PEI membrane may affect several cytokines relating to the progress of liver diseases in company with bilirubin clearance. |
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| Keywords: | Affinity membrane Cytokines Immune index |
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