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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity |
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| Institution: | 1. Ribon Therapeutics, 35 Cambridgepark Drive, Suite 300, Cambridge, MA 02140, USA;2. Patricia E. Rao Consulting, Acton, MA 01720, USA;3. Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Warren Alpert 536, Boston, MA 02115, USA |
| Abstract: |  |
| Keywords: | PARP7 cancer drug discovery type I interferon nucleic acid sensing DNA sensing innate immunity small-molecule inhibitor RBN-2397 |
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