Prognostic Value of Natural Killer Cells Besides Tumor-Infiltrating Lymphocytes in Breast Cancer Tissues |
| |
| Affiliation: | 1. Department of Pathology and Research Laboratory LR18SP10, University Hospital Habib Bourguiba, Sfax, Tunisia;2. Medical School of Sfax, University of Sfax, Sfax, Tunisia;3. Laboratory of Molecular and Cellular Screening Processes LR15CBS07, Centre de Biotechnologie de Sfax, University of Sfax, Sfax, Tunisia;4. Department of Medical Oncology, University Hospital Habib Bourguiba, Sfax, Tunisia;5. Department of Gynecology and Obstetrics, University Hospital Hedi Chaker, Sfax, Tunisia;1. Plastic Surgery Unit, Department of Medical Biotechnology and Translational Medicine BIOMETRA, Humanitas Clinical and Research Hospital, Reconstructive and Aesthetic Plastic Surgery School, University of Milan, Rozzano, Milan, Italy;2. UO of Medical Oncology, Department of Oncology Hematology, Humanitas Clinical and Research Center, Istituto di Ricovero e Cura a Carattere Scientifico, Rozzano, Milan, Italy;3. Breast Surgery Department, Humanitas Clinical and Research Center, Istituto di Ricovero e Cura a Carattere Scientifico, Rozzano, Milan, Italy;4. Humanitas University Department of Biomedical Sciences, Pieve Emanuele, Milan, Italy;1. Hospital Sirio Libanes, Adma Jafet St 91, 1308050 São Paulo, Brazil;2. Ramon y Cajal University Hospital, Ctra. Colmenar Viejo km. 9, 100, 28034 Madrid, Spain;3. European Institute of Oncology, Via Ripamonti 435, 20146 Milano, Italy;4. Peter MacCallum Cancer Centre, University of Melbourne, Grattan Street 305, 3000 Melbourne, Australia;5. Institute of Pathology, Charité Universitätsmedizin Berlin and German Cancer Consortium (DKTK), Campus Mitte, Charitéplatz 1, D-10117 Berlin, Germany;6. Baselga Oncological Institute, Quiron Hospital, Plaça d''Alfonso Comín 5, 08023 Barcelona, Spain;7. Vall d''Hebron Institute of Oncology, Centro Cellex, Calle Natzaret 115–117, 08035 Barcelona, Spain;8. Baselga Institute of Oncology, Madrid, Spain |
| |
| Abstract: | BackgroundEach subgroup of immune cells has a different prognostic role in breast cancer; however, the prognostic impact of tumor-infiltrating natural killer cells (TINKs) is still not well established. Our aim was to assess the prognostic impact of natural killer (NK) cells in breast carcinomas.Materials and MethodsNK cells infiltration were assessed by immunohistochemistry (IHC). Statistical analyses were performed to evaluate the correlation of NK cells with clinical-pathological features and outcome.ResultsCD56 IHC was realized in 126 patients. NK cells infiltration showed significant and positive association with tumor high Scarff-Bloom-Richardson (SBR) grade. NK cells were significantly associated with HER2-positive breast cancer and triple-negative breast cancer subtypes. Analyses showed significant and inverse correlation with progesterone and estrogen receptors expression status. High NK cells were significantly related to high Ki-67 labeling index. Our data showed that high NK cells infiltrate was significantly associated with tumor-infiltrating lymphocytes in breast cancer tissues.At a median follow-up of 5.5 years, high CD56 expression (≥ 5 cells/10 high power field) was associated significantly with a good overall survival and with good disease-free survival.ConclusionIn this study, we assessed the important prognostic role of TINKs in breast carcinomas, which seems to be evident despite its association with aggressive pathological features. Thus evaluation of NK cells can be standardized and integrated in daily routine. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
