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TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
Affiliation:1. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA;2. The Broad Institute of MIT and Harvard, Cambridge, MA, USA;3. Division of Pediatric Hematology/Oncology, Boston Children''s Hospital, Boston, MA, USA;4. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA;5. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA;6. Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA;7. Howard Hughes Medical Institute, University of California, Berkeley, CA, USA;8. Dr.von Hauner Children''s Hospital, Department of Pediatrics, University Hospital, LMU Munich, Munich, Germany;9. CIRM Center of Excellence, University of California, Berkeley, CA, USA
Abstract:
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  • Keywords:fusion oncoproteins  EWS/FLI  Ewing sarcoma  TRIM8  E3 ligases  ubiquitination  protein degradation  neomorphic substrate  tumor dependency  oncogene overdose
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