The Evolving Field of Neoadjuvant Therapy in Locally-advanced Rectal Cancer: Evidence and Prospects |
| |
| Institution: | 1. Division of Clinical Research, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil;2. Department of Abdomino-Pelvic Surgery, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil;1. Department of Oncology, Oslo University Hospital, Oslo, Norway;2. Leeds Institute of Medical Research, University of Leeds, Leeds, UK;3. Department of Translational Medicine, University of Eastern Piedmont and Department of Radiation Oncology, AOU ‘’Maggiore della Carità,’’ Novara, Italy;4. Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden;5. School of Clinical Sciences, Faculty of Medicine, Monash University, Clayton, Australia and Department of Oncology, Monash Health Clayton, Australia;6. Institute Gustave Roussy, Villejuif, France;7. GI Unit, Royal Marsden Hospital, London, UK;8. Department of Oncology, Aarhus University Hospital, Aarhus, Denmark;9. Asklepios Tumorzentrum Hamburg, AK Altona, Hamburg, Germany;1. Department of Medicine;2. Department of Radiology;3. Department of Histopathology;4. Department of Clinical Research & Development, The Royal Marsden NHS Foundation Trust, London and Surrey, UK;5. Department of Medical Oncology, Vall d''Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain;6. Department of Immunology, Genetics and Pathology, Section of Experimental and Clinical Oncology, University of Uppsala, Uppsala, Sweden;7. Department of Haematology and Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia, Valencia, Spain |
| |
| Abstract: | The standard treatment of locally advanced rectal cancer comprises neoadjuvant chemoradiation followed by total mesorectal excision. This strategy provides low local recurrence rate, however distant recurrence is still an issue and may impact on survival rates. Novel approaches in the neoadjuvant setting have been tested to improve early and late outcomes, as well as to reduce treatment-related toxicity and morbidity. In this review, we discuss the current literature of neoadjuvant treatment in locally advanced rectal cancer, including total neoadjuvant methods, protocols for radiation delivery, chemotherapy regimen and efforts to add novel targeted therapies, selective withdrawal of surgery or radiotherapy, and future perspectives. Moreover, we highlight relevant issues that have emerged with these new treatment possibilities. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
