Disease Burdens of Alzheimer's Disease,Vascular Dementia,and Mild Cognitive Impairment |
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| Institution: | 1. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;2. Department of Psychiatry, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea;3. Department of Psychiatry, Yonsei University Wonju Severance Christian Hospital, Wonju, Republic of Korea;4. Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, Republic of Korea;5. Department of Psychiatry, Gyeongsang National University School of Medicine, Jinju, Republic of Korea;6. Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea;7. Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Republic of Korea;8. Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Chungju Hospital, Chungju, Republic of Korea;9. Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Republic of Korea;10. Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Medical Center, Seoul, Republic of Korea;11. Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, Republic of Korea;12. Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea;13. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea;14. Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea;15. Department of Psychiatry, Dankook University Hospital, Cheonan, Republic of Korea;p. Department of Psychiatry, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea;q. Department of Brain and Cognitive Science, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea;1. Division of Health Policy & Management, School of Public Health, University of Minnesota, Minneapolis, MN, USA;2. College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA;3. Cecil G. Sheps Center for Health Services Research and Schools of Social Work and Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;1. Alzheimer''s Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d''Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;2. Barcelona βeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain;3. Department of Psychology, Brooklyn College and The Graduate Center of CUNY, Brooklyn, NY, USA;4. Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA;5. Center for Alzheimer Research and Treatment, Brigham and Women''s Hosptial and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;6. Florey Institute of Neuroscience and Mental Health, Melbourne, Australia;7. Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia;8. Institute of Memory and Alzheimer''s Disease and Brain and Spine Institute (ICM) Pitié Salpetriere University Hospital, Sorbonne Universities, Pierre et Marie Curie University, Paris, France;9. Department of Psychiatry, Royal Melbourne Hospital, The University of Melbourne, Melbourne, Australia;10. Institute for Stroke and Dementia Research, Klinikum der Universität München Ludwig-Maximilians-Universität LMU, Munich, Germany;11. AXA Research Fund & UPMC Chair, Paris, France;12. Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany;13. Center of Geriatrics and Gerontology, University Medical Center Freiburg, Freiburg, Germany;14. Department of Psychiatry, New York University Langone Medical Center, New York, NY, USA;15. Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA;p. Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA;q. Department of Neurology, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands;r. Department of Epidemiology and Biostatistics, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands;s. Neuroscience Campus Amsterdam, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands;t. Department of Psychology, University of Victoria, Victoria, BC, Canada;u. Institute on Aging and Lifelong Health, University of Victoria, Victoria, BC, Canada;v. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA;w. Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany;x. German Center for Neurodegenerative Disorders (DZNE), Bonn-Cologne, Germany;y. Department of Psychiatry, University Hospital Cologne, Medical Faculty, Cologne, Germany |
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| Abstract: | ObjectivesUnderstanding disability-adjusted life-years (DALYs) based on dementia subtypes and mild cognitive impairment (MCI) is essential for optimal resource allocation. This study aimed to investigate disease burdens of various dementias and MCI in a representative South Korean population.DesignRetrospective cohort study.Setting and Participants6481 Korean older adults.MethodsWe estimated the disease-specific DALYs.ResultsDALYs due to MCI and all-cause dementia are estimated to increase from 1295 per 100,000 in 2016 to 9501 per 100,000 in 2065. In 2016, DALYs attributed to Alzheimer's dementia, vascular dementia, and MCI accounted for 33% (423 per 100,000), 20% (316 per 100,000), and 24% (123 per 100,000), respectively, of the total DALYs due to MCI and all-cause dementia. In 2065, DALYs due to Alzheimer's dementia, vascular dementia, and MCI will account for 38% (3654 per 100,000), 17% (1654 per 100,000), and 27% (2585 per 100,000) of total DALYs due to MCI and all-cause dementia, respectively.The years of life lived with disability (YLDs) due to MCI and all-cause dementia are estimated to rise from 479 per 100,000 in 2016 to 2807 per 100,000 in 2065. In 2016, YLDs due to Alzheimer's dementia, vascular dementia, and MCI composed 37% (177 per 100,000), 18% (85 per 100,000), and 15% (70 per 100,000), respectively, of the total YLDs due to MCI and all-cause dementia. In 2065, YLDs due to Alzheimer's dementia, vascular dementia, and MCI will account for 48% (1358 per 100,000), 15% (410 per 100,000), and 10% (290 per 100,000), respectively, of total YLDs due to MCI and all-cause dementia.Conclusions and ImplicationsConsidering the rapidly growing disease burden, resources should be allocated to continuously monitor and manage the MCI and dementia burden. Particular attention to Alzheimer's dementia is required considering its significant contribution to current and future disease burden, especially to YLD. |
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| Keywords: | Disability-adjusted life-year mild cognitive impairment dementia vascular dementia Alzheimer's dementia |
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