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Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation
Institution:1. Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA;2. Ludwig Institute for Cancer Research, Lausanne Branch, Department of Oncology, University of Lausanne (UNIL) and Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland;3. Bioinformatics Core Facility, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland;4. Research Program of Systems Oncology, University of Helsinki, 00014 Helsinki, Finland;5. Center for Precision Oncology, Department of Oncology, CHUV, 1011 Lausanne, Switzerland;6. Center of Experimental Therapeutics, Department of Oncology, CHUV, 1011 Lausanne, Switzerland;7. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;8. Harvard Ludwig Center, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA;9. National Center for Cancer Immune Therapy, Copenhagen University Hospital, 2730 Herlev, Denmark;10. Department of Oncology, UNIL, 1011 Lausanne, Switzerland;11. Department of Obstetrics and Gynecology, Helsinki University Hospital, 00014 Helsinki, Finland;12. 2nd Department of Pathology, National and Kapodistrian University of Athens, 15771 Athens, Greece
Abstract:
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  • Keywords:tumor  ovarian  TIL  exhaustion  CD28  PD-1  CTLA-4  CD40  myeloid niche  dendritic cell
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