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Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification
Institution:1. The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA;2. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA;3. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA;4. Department of Oncology Biomarker Development, Genentech, South San Francisco, CA, USA;5. Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA;6. Department of Dermatology and Skin Cancer, APHM, CHU Timone, Aix-Marseille University, Marseille, France;7. Nantes Université, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, 44000 Nantes, France;8. CHU Nantes, Nantes Université, Laboratoire d’Immunologie, 44000 Nantes, France;9. Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA;10. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA;11. Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA;12. Immuno-oncology Drug Discovery Unit, Millennium Pharmaceuticals, Inc. a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Tokyo, Japan;13. Department of Oncology & Angiogenesis, Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA;14. Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA;15. Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA, USA;16. Department of Cancer Immunology, Genentech, South San Francisco, CA, USA;17. Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA;18. Institute for Thoracic Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Abstract:
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  • Keywords:NSCLC  immunotherapy  macrophages  dendritic cells  tumor microenvironment  tumor-associated myeloid cells  tumor mutational burden  CITEseq  tumor cell atlas  high dimensional profiling
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