A Quantitative Method of Evaluating the Diuretic Response to Furosemide in Rats |
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| Authors: | Ryohei Hori Katsuhiko Okumura Ken-ichi Inui Takashi Shibata Toshihiro Kikkoji Akira Kamiya |
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| Affiliation: | Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan. |
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| Abstract: | Furosemide effects are usually evaluated by measuring the urinary excretion rate of Na+ (UVNa) in humans. In the present study, however, UVNa showed a nonlinear relationship with urine flow rate after intravenous injection of furosemide in rats. In contrast, when the urinary excretion rate of (Na+ + K+) (UVNa+K) was plotted against the urine flow rate, a linear regression line was observed, with small interindividual variations in normal rats and in rats with uranyl nitrate-induced acute renal failure (ARF). Piretanide, a loop diuretic, also showed a similar relationship, while other types of diuretics revealed different slope values for the relationship. Although the urinary excretion rate of Cl– (UVC1) vs UVNa+K is expected to show a linear relationship in normal rats, the correlation coefficient of the linear regression line was smaller than that of the urine flow rate vs UVNa+K. Further, the slope of UVC1 vs UVNa+K was slightly different in ARF rats. Therefore, UVNa+K provides a better quantitative measure of diuretic response to loop diuretics than UVNa or UVC1. |
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| Keywords: | furosemide diuresis sodium excretion potassium excretion chloride excretion urinary excretion rate urinary electrolytes in rats |
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