The fat-to-lean mass ratio,a novel anthropometric index,is associated to glucose metabolic disorders |
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| Institution: | 1. Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Canada;2. Faculty of pharmacy, Laval University, Québec, Canada;1. Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA;2. Amsterdam UMC, University of Amsterdam, Department of General Practice, Amsterdam Cardiovascular Sciences Research Institute, The Netherlands;1. 7th Respiratory Medicine Department and Asthma Center, Chest Hospital \"Sotiria\", 152 Mesogeion Avenue, Athens 11527, Greece;2. Pulmonary Department, “G.Papanikolaou” Hospital, Aristotle University of Thessaloniki,Papanikolaou Avenue, Thessaloniki 57010, Greece;3. Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, BIOPOLIS, Larissa 41110, Greece;4. Department of Pulmonary Medicine, 401 General Army Hospital, P.Kanellopoulou Avenue, Athens 11525, Greece;5. 1st Department of Critical Care and Pulmonary Medicine, \"Evangelismos\" Hospital, National and Kapodistrian University of Athens, 45-47 Ipsilantou Street, Athens 10676, Greece;1. Department of Cardiology, Santa Maria della Misericordia Hospital, Rovigo, Italy;2. Section of Internal and Cardiopulmonary Medicine, University of Ferrara, Faculty of Medicine, Ferrara, Italy;3. Division of Infectious Disease, Santa Maria della Misericordia Hospital, Rovigo, Italy;1. Crozer-Chester Medical Center, Upland, PA, USA;2. Deccan College of Medical Sciences, Hyderabad, India;3. Mount Sinai St Luke''s Roosevelt Hospital, New York, USA;4. Westchester Medical Center, New York Medical College, Valhalla, NY, USA;5. Albert Einstein Medical Center, Philadelphia, PA, USA |
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| Abstract: | ObjectiveThe aim was to evaluate whether the Fat-to-Lean Mass (FyM) ratio is associated to glucose metabolic disorders (GMD).DesignCross-sectional population based study.MethodsEligible subjects were healthy men and non-pregnant women with new diagnosis of GMD that were allocated into following groups: 1) Normal Glucose Tolerance (NGT), 2) Diabetes, 3) impaired fasting glucose (IFG) + impaired glucose tolerance (IGT), 4) IGT, and 5) IFG. The FyM index Total body fat (Kg)/total lean mass (Kg)], and the odds ratio (OR) between FyM index and GMD were estimated.ResultsA total of 875 individuals with average age 41.62 ± 12.3 were enrolled; of them, 645 (73.1%) women and 230 (22.8%) men; 521 (59.5%), 71 (8.1%), 85 (9.7%), 53 (6.0%), and 145 (16.6%) individuals were allocated into groups with NGT, diabetes, IFG + IGT, IGT, and IFG, respectively. The FyM was significantly associated with prediabetes and diabetes in women (OR 4.2; 95%CI 3.0–11.1 and OR = 7.2; 95%CI 2.0–15.2) and men (OR = 2.6; 95%CI 1.1–6.7 and OR = 4.6; 95%CI 1.4–15.1). In the overall population, the OR between FyM index with IGT, IFG, and IFG + IGT was 8.4 (95%CI 2.6–17.4), 5.2 (95%CI 2.6–10.6), and 6.1 (95%CI 1.8–9.5).ConclusionThe FyM index was strongly associated with all categories of GMD. |
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