A Probiotic Lactobacillus gasseri Alleviates Escherichia coli-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota |
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| Authors: | Soo-Won Yun Jeon-Kyung Kim Kyung-Eon Lee Young Joon Oh Hak-Jong Choi Myung Joo Han Dong-Hyun Kim |
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| Affiliation: | 1.Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Korea; (S.-W.Y.); (M.J.H.);2.Neurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea; (J.-K.K.); (K.-E.L.);3.Division of Research and Development, World Institute of Kimchi, Gwangju 61755, Korea; (Y.J.O.); (H.-J.C.) |
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| Abstract: | Excessive expression of interleukin (IL)-1β in the brain causes depression and cognitive dysfunction. Herein, we investigated the effect of Lactobacillus gasseri NK109, which suppressed IL-1β expression in activated macrophages, on Escherichia coli K1-induced cognitive impairment and depression in mice. Germ-free and specific pathogen-free mice with neuropsychiatric disorders were prepared by oral gavage of K1. NK109 alleviated K1-induced cognition-impaired and depressive behaviors, decreased the expression of IL-1β and populations of NF-κB+/Iba1+ and IL-1R+ cells, and increased the K1-suppressed population of BDNF+/NeuN+ cells in the hippocampus. However, its effects were partially attenuated by celiac vagotomy. NK109 treatment mitigated K1-induced colitis and gut dysbiosis. Tyndallized NK109, even if lysed, alleviated cognitive impairment and depression. In conclusion, NK109 alleviated neuropsychiatric disorders and colitis by modulating IL-1β expression, gut microbiota, and vagus nerve-mediated gut–brain signaling. |
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| Keywords: | Lactobacillus gasseri, cognition impairment, depression, IL-1β , gut microbiota |
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