氯化钾氯化钠注射液与常用抗菌药物配伍的稳定性研究

目的：了解氯化钾氯化钠注射液与常用抗菌药物配伍后,是否产生药效降低或毒性增加等变化。方法：在室温下,体外实验：将氯化钾氯化钠注射液于临床常用使用浓度与常用抗菌药物配伍后,在0、30、60、120min分别观察外观、PH值、渗透压摩尔浓度、浊度、含量等变化;体内实验：将氯化钾氯化钠注射液于2个浓度（临床常用浓度,2倍临床常用浓度）的常用13种抗生素配伍后,静脉滴注家兔,记录给药前及给药后5、18、30和60min的心电图及呼吸频率。结果：在室温下,氯化钾氯化钠注射液与13种抗菌药物配伍后,在不同时间内观察到的理化性质与对照组无明显差别;静脉滴注氯化钾氯化钠注射液与抗菌药物配伍后的溶液,在不同时间内测定的呼吸及心率无明显变化。结论：室温条件下,氯化钾氯化钠注射液与常用抗菌药物配伍稳定,不会产生药效降低或毒性增加等变化。

Stability study of compatibility of potassium chloride sodium chloride injection and commonly used antimicrobial drugs

Objective： Understand potassium chloride sodium chloride injection and commonly used antimicrobial drug compatibili-ty, whether to produce toxic effects to reduce or increase change. Methods： In vitro experiments： Under ambient conditions, to stud-y the changes of appearance, pH value, osmotic pressure molar concentration, turbidity and purity, clinically relevant concentrations of the potassium chloride and sodium chloride injection were mixed with several antibacterial agents, and observed the changes at 0, 30, 60 and 120 min, In vivo experiments： Clinically relevant concentrations of the potassium chloride and sodium chloride injection and double it was respectively mixed with 13 antibacterial agents, and then, the mixture was attached to an intravenous drip to rab-bits. At the same time, ECG and respiratory rate was recorded after 5, 18, 36 min. Result： At room temperature, potassium chlo-ride and sodium chloride injection was mixed with 13 antibacterial agents, the physical and chemical properties were no significant difference observed with the control group at different times. Conclusion： At room temperature, there was no change in reduced effi-cacy or increased toxicity of the mixture of the potassium chloride and sodium chloride iniection with commonly used antibiotics, and the mixture was stable.