多索茶碱与噻托溴铵粉联合治疗对慢阻肺患者肺功能影响的临床观察

目的：探讨多索茶碱与噻托溴铵粉联合治疗慢阻肺对肺功能的影响。方法：选取2009年7月至2012年11月在我院进行治疗慢阻肺患者114例,随机分为观察组和对照组,观察组采用多索茶碱与噻托溴铵粉联合治疗,对照组给予多索茶碱单独治疗,比较疗效。结果：观察组有效率为96.49%,对照组有效率为70.18%;治疗后,观察组与对照组的社会活动、日常生活、焦虑、抑郁评分以及总分、FEV1、FVC、FEV1/FVC水平差异显著（P〈0.05）。结论：多索茶碱与噻托溴铵粉联合治疗慢阻肺,可显著改善患者肺功能,提高治疗疗效,提高患者生活质量,值得临床运用。

Clinical observation of effects of doxofylline and tiotropium olfactory ammonium powder combined therapy on pulmonary function in chronic obstructive pulmonary disease

Objective： To investigate the effects of doxofylline and tiotropium olfactory ammonium powder combined therapy on pulmonary function in chronic obstructive pulmonary disease. Methods： 114 cases of chronic obstructive pulmonary disease from 2009 July to 2012 November in our hospital were randomly divided into the observation group and the control group. The patients from observation group and control group were treated with doxofylline combined with tiotropium olfactory ammonium powder and doxofylline alone, respectively. The efficacy of doxofylline combined with or without tiotropium olfactory ammonium powder was compared. Results： The effective rates of the observation group and the control group were 96. 49% and 70. 18%, respectively. Compared with control group, social activities, daily life, anxiety, depression score and total score, FEV1, FVC, FEV1/FVC were significantly improved after doxofylline combined with tiotropium olfactory ammonium powder treatment （P〈0. 05）. Conclusion： Doxofylline combined with tiotropium olfactory ammonium powder in the treatment of chronic obstructive pulmonary disease, can sig-nificantly improve pulmonary function, improve curative effect and the patients＇ quality of life. It is worthy of clinical application.