99mTc-HL91 is inferior to 201Tl in scintigraphic detection of chronic myocardial ischaemia |
| |
Authors: | Wu Yen-Wen Lee Chii-Ming Huang Yi-Hwen Chou Nai-Kuan Yen Ruoh-Fen Tzen Kai-Yuan Huang Por-Jau |
| |
Institution: | Departments of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. |
| |
Abstract: | AIM: 99mTc-HL91 is a new hypoxia agent and can identify acutely ischaemic viable myocardium in a canine model using a standard gamma camera. The purpose of the study was to determine whether this tracer could be used to detect regional ischaemia in chronic ischaemic myocardium in a swine model. METHOD: Using a porcine model of chronic myocardial ischaemia, five mini-pigs with proximal left anterior descending artery (LAD) stenoses were studied. Injection of 462.5 MBq (12.5 mCi) 99mTc-HL91 was followed by imaging over 2 h. Coronary angiography and dipyridamole stress-re-injection 201Tl single photon emission computed tomography (SPECT) were performed within 1 day of each other. RESULTS: None of the five pigs demonstrated positive hot 99mTc-HL91 uptake throughout the 2 h imaging, whereas four of the five animals showed significant myocardial ischaemia on 201Tl SPECT. The region of interest analysis of LAD/left circumflex artery count ratios at 1 and 2 h demonstrated similar 99mTc-HL91 uptake and retention in chronic ischaemic as well as non-ischaemic myocardium. CONCLUSION: 99mTc-HL91 is inferior to 201Tl in scintigraphic detection of chronic myocardial ischaemia. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|