眼球震颤婴幼儿的视网膜电图

目的:了解眼球震颤婴幼儿视网膜电图(Electroretinogram,ERG)测试的特点及其临床应用意义。方法:根据国际临床视觉电生理学会ERG标准化方案,应用日本光电公司生产的Neuropack MEB-2200K电生理仪对出生2个月至72个月的眼球震颤婴幼儿共46例(92只眼)进行测试。结果:46例(92只眼)眼球震颤婴幼儿中,除1例(2只眼)在闪烁光刺激时无法记录到ERG闪烁光反应外,其余病例皆可记录到5种类型的ERG。其中视杆细胞ERG、标准混合ERG、振荡电位、单次闪光视锥ERG和30Hz闪烁光反应的异常率分别为65%,86%,61%,77%和62%。若对每1只眼5种类型ERG进行综合评估,有5只眼表现为单纯视杆反应降低、11只眼表现为以视杆反应改变为主的杆锥反应异常、14例表现为单纯视锥反应降低、23只眼表现为以视锥反应改变为主的锥杆反应异常、8只眼表现为单纯混合反应异常、8只眼表现为全部记录不到反应的熄灭型,各有5只眼出现全部ERG的轻度下降、中度下降、重度下降,仅8只眼记录到正常ERG。结论:眼球震颤婴幼儿的ERG异常率达91%,表明视网膜的异常在眼球震颤的发病机制中起着重要的作用。

The Electroretinogram of Infants with Nystagmus

Purpose:To find the characteristics and clinical application of electroretinogram(ERG)in infants with nystagmus.Method:Forty-six cases(92 eyes)of infants with nystagmus(aged 2-72 months old)were tested with Neuropack MEB-2200K system according to the ERG standard of ISCEV.Results:Five kinds of ERG responses of all subjects but one could be recorded.The abnormal rates of the rod ERG,standard mixture ERG,oscillatory potentials,single-flash cone ERG and 30 Hz flicker response were 65%,86%,61%,77% and 62% respectively.The ERG abnormalities were evaluated from the 5 responses.The rod ERG decreased in 5 eyes.The rod-cone ERG decreased in 11 eyes.The cone ERG decreased in 14 eyes.The cone-rod ERG decreased in 23 eyes.The standard mixture ERG decreased in 8 eyes.The ERG was unrecordable in 8 eyes.The mild,middle,and severe decreases of rod and cone ERG appeared in 5 eyes respectively.The normal ERG was only recorded in 8 eyes.Conclusion:Abnormal rate of ERG is 91% in infants with nystagmus.The retina abnormality may pay an important role in the pathogenesis of nystagmus.