病毒性肝炎患者血清IV型胶原变化及临床意义

对２０８例病毒性肝炎患者检测血清ＩＶ型胶原，其结果提示急性肝炎患者与正常组比较无统计学意义。慢性迁延型、慢性活动型及慢性重症肝炎＋肝硬化（失代偿）三组患者中，其含量均高，其升高程度与肝病的临床和组织学严重性相关。在各组肝炎活动期和恢复期，其含量变化无统计学意义。血清ＩＶ型胶原的测定对慢性肝病纤维化严重程度和预后的判断有重要临床意义。

THE CHANGE OF SERUM COLLAGEN IV LEVEL AND ITS CLINICAL SIGNIFICANCE IN PATIENTS WITH VIRAL HEPATITIS

Hepatic fibrosis means the increase of fibrous connective tissue including cellular components and extracellular matrix in the liver. Collagen is the one of main matrix components. Serum collagen IV level of 208 patients with viral hepatitis was determined. There was no significant difference between the acute hepatitis and normal control. Serum collagen IV level was elevated in the groups of chronic persistent hepatitis, chronic active hepatitis, and chronic severe hepatitis or cirrhosis(decompensation). The extent of elevated serum collagen IV level was correlated with clinical manifestations and histological findings. There was no significant difference in serum collagen IV level between active and convalescent periods for various groups. The measurement of serum collagen IV is very important for assessment of grade of hepatic fibrosis and prognosis of chronic hepatitis.