Effect of an intranasal LHRH agonist on gonadotrophins and hot flushes in post-menopausal women |
| |
Authors: | R W Shaw R H Kerr-Wilson H M Fraser A S McNeilly P W Howie J Sandow |
| |
Affiliation: | 1. Department of Obstetrics and Gynaecology, Edinburgh University, U.K.;2. MRC Centre for Reproductive Biology, Edinburgh, U.K.;3. Hoechst, A.G., 6230 Frankfurt, F.R.G. |
| |
Abstract: | Alterations in circulating gonadotrophins have been reported at the time of onset of menopausal flushes. In order to study this association D-SER(TBU)6-EA10-LHRH, a luteinizing hormone releasing hormone (LHRH) agonist was given intranasally at a dose of 200 micrograms twice daily to 12 post-menopausal women to study its effect on gonadotrophin secretion and hot flushes. Following an initial period of 3-5 days of increased gonadotrophin secretion, pituitary desensitization occurred, with a significant suppression of circulating LH and follicle-stimulating hormone (FSH) levels (P less than 0.001) and a reduction in gonadotrophin pulse amplitude (P less than 0.05). This was accompanied by a significant diminution of the pituitary's response to exogenous LHRH (P less than 0.05). However, no significant alteration in the incidence of hot flushes was observed on such therapy. |
| |
Keywords: | Menopause LHRH agonist Gonadotrophins |
本文献已被 ScienceDirect 等数据库收录! |
|