| CD3+CD28+T细胞与晚期非小细胞肺癌化疗疗效的相关性研究 |
| |
| 引用本文： | 杨绿英,黄丽蓉,贾非非,章春,胡守喜. CD3+CD28+T细胞与晚期非小细胞肺癌化疗疗效的相关性研究[J]. 临床军医杂志, 2011, 39(6). DOI: 10.3969/j.issn.1671-3826.2011.06.24 |
| |
| 作者姓名： | 杨绿英 黄丽蓉 贾非非 章春 胡守喜 |
| |
| 作者单位： | 1. 四川省革命伤残军人医院,四川 成都,610501
2. 山西省肿瘤医院,山西太原,030013 |
| |
| 摘 要： | 目的探讨CD3+CD28+T细胞与晚期非小细胞肺癌化疗疗效的相关性。方法 40例有可测量病灶的晚期非小细胞肺癌患者接受NP方案化疗,化疗前采用流式细胞术检测外周血CD3+CD28+T细胞的数值,进行有效组(CR+PR)、稳定组(SD)、进展组(PD)和正常对照组四组间比较,并进行疗效与CD3+CD28+T细胞值的相关性分析。结果化疗前有效组的CD3+CD28+T细胞值与对照组相比差异无统计学意义(P=0.158),稳定组和进展组均低于对照组(P=0.003,P=0.000);有效组明显高于稳定组和进展组(P=0.036,P=0.000),稳定组高于进展组(P=0.000)。疗效与CD3+CD28+T细胞数值的相关系数r=0.672(P=0.000)。结论化疗前CD3+CD28+T细胞检测值与化疗疗效有一定的相关性,化疗前CD3+CD28+T细胞数值高,则化疗效果好。
|
| 关 键 词： | 晚期非小细胞肺癌 CD3+CD28+T细胞 化疗 疗效预测 |
A study of correlation between CD3~+CD28~+T cell value and chemotherapy in patients with advanced non-small cell lung cancer |
| |
| Yang Lv-ying,Huang Li-rong,Jia Fei-fei,Zhang Chun,Hu Shou-Xi. A study of correlation between CD3~+CD28~+T cell value and chemotherapy in patients with advanced non-small cell lung cancer[J]. Clinical Journal of Medical Officer, 2011, 39(6). DOI: 10.3969/j.issn.1671-3826.2011.06.24 |
| |
| Authors: | Yang Lv-ying Huang Li-rong Jia Fei-fei Zhang Chun Hu Shou-Xi |
| |
| Affiliation: | Yang Lv-ying1,Huang Li-rong1,Jia Fei-fei1,Zhang Chun1,Hu Shou-Xi2(1.Sichuan Revolutionary Disability Armyman Hospital,Chengdu Sichuan 610501,China,2.Shanxi Tumor Hospital,Taiyuan Shanxi 030013,China) |
| |
| Abstract: | Objective To explore the correlation between CD3+CD28+T cell value and chemotherapy in patients with advanced non-small cell lung cancer(NSCLC). Methods By flow cytometry,the absolute counts of CD3+CD28+T cells in peripheral blood from 40 patients with advanced NSCLC were detected before chemotherapy.All the patients with measurable tumor accepted NP Chemotherapy.The chemotherapeutic efficacy was determined in four groups:complete response plus partial response(CR+PR),stable disease(SD) and progressive dise... |
| |
| Keywords: | advanced NSCLC CD3 CD28 T cell chemotherapy efficacy prediction |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
