| 蛇床子素内酯环完整性对抑真菌活性的影响 |
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| 引用本文： | 兰树敏,梅清华,林敬明,龚文菲,林茂锐.蛇床子素内酯环完整性对抑真菌活性的影响[J].中国医药导报,2010,7(24):20-21. |
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| 作者姓名： | 兰树敏 梅清华 林敬明 龚文菲 林茂锐 |
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| 作者单位： | 1. 广东省第二人民医院,广东广州,510317
2. 南方医科大学珠江医院,广东广州,510282 |
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| 基金项目： | 广东省中医药局资助课题 |
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| 摘 要： | 目的：观察蛇床子素内酯环完整性对其抑临床常见浅部真菌活性的影响。方法：配制pH=4和pH=9的蛇床子素溶液,以K-B法比较其对须毛癣菌、红色毛癣菌和石膏样小孢子菌的抑菌活性。结果：在pH=4和pH=9时对三种真菌的抑菌圈直径对比分别为32mm∶22mm（P〈0.01）、35mm∶37mm（P〉0.05）和31mm∶29mm（P〉0.05）。结论：蛇床子素内酯环开环前对三种真菌均表现出较好抑菌活性,开环后对须毛癣菌抑菌活性消失,但对石膏样小孢子菌和红色毛癣菌则没有影响。
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| 关 键 词： | 蛇床子素 浅部真菌 须毛癣菌 红色毛癣菌 石膏样小孢子菌 |
Effect on superficial mycosis of the integrality of Osthole's lactonic ring |
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| LAN Shumin,MEI Qinghua,LIN Jingming,GONG Wenfei,LIN Maorui.Effect on superficial mycosis of the integrality of Osthole's lactonic ring[J].China Medical Herald,2010,7(24):20-21. |
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| Authors: | LAN Shumin MEI Qinghua LIN Jingming GONG Wenfei LIN Maorui |
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| Institution: | 1.The Second People＇s Hospital of Guangdong Province,Guangzhou 510317,China;2.Zhujiang Hospital of Southern Medical University,Guangzhou 510282,China) |
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| Abstract: | Objective：To observe the effect on superficial mycosis of the integrality of ostholes lactonic ring.Methods：Prepared the osthole solutions of pH=4 and pH=9,compared antifungal activity to T.mentagrophytes,T.purpureatum,and Microsporum gypseum by Kirby-Bauer method.Results：The Diameter of inhibition zone of pH=4 compared to that of pH=9 in three funguses were 32 mm∶22 mm（P0.05）,35 mm∶37 mm（P0.05） and 31 mm∶29 mm（P0.05）.Conclusion：Osthole with integrated lactonic ring had antifungal activity to three funguses.When lactonic ring was broken antifungal activity to T.mentagrophytes disappeared,but no difference was observed to T.purpureatum,and Microsporum gypseum. |
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| Keywords: | Osthole Superficialmycosis T mentagrophytes T purpureatum Microsporum gypseum |
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