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| 引用本文： | 郑昭芬 蒲晓群 杨天<,IMG height= alt=. 地尔硫![[J].]()
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| 作者姓名： | 郑昭芬 蒲晓群 杨天< IMG height= alt= |
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| 作者单位： | 中南大学湘雅医院心血管内科,长沙,410008 |
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| 摘 要： |
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| 关 键 词： | 地尔硫(艹卓) 急性心肌梗死 血管成形术 支架 无再流现象 |
| 文章编号： | 1672-7347（2006）06-0917-04 |
| 收稿时间： | 2005-12-13 |
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| Authors: | < FONT face= |
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| Affiliation: | Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China. |
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| Abstract: | OBJECTIVE: To assess the effects of intracoronary diltiazem on no-reflow phenomenon of infarct-related artery (IRA) after emergent percutaneous transluminal coronary angioplasty or/and intracoronary stenting (PTCA/Stenting) in the patients with acute myocardial infarction (AMI). METHODS: We studied 34 AMI patients with no-reflow phenomenon of IRA after emergent PTCA/Stenting between January 1999 and August 2005. Urokinase-treated group (n=16) was given intracoronary urokinase 30,0000 - 50,0000 units within 15 - 30 minutes between January 1999 and April 2002 while diltiazem-treated group (n=18) was given intracoronary diltiazem 0.5 - 2 mg within 10 - 30 minutes between May 2002 and August 2005. Fifteen minutes later, coronary arteriography (CAG) was performed and the thrombolysis in myocardial infarction (TIMI) flow grade was measured. RESULTS: No apparent change of TIMI flow grade was found between pre-administration and post-administration of intracoronary urokinase, but TIMI flow grade was significantly improved after intracoronary diltiazem (P<0.01). TIMI flow grade of diltiazem-treated group was significantly higher than that of urokinase-treated group after the administration (P<0.05). The percentage of the patients who reached TIMI flow grade 3 after the intracoronary administration was higher in the diltiazem-treated group than that in the urokinase-treated group (P<0.01). CONCLUSION: The intracoronary administration of diltiazem 0.5~2mg can effectively improve the no-reflow phenomenon after emergent PTCA/Stenting in patients with AMI. |
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| Keywords: | dihiazem acute myocardial infarction percutaneous transluminal coronary angioplasty intracoronary stenting no-reflow phenomenon |
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