经主动脉瓣插管左心室辅助的研究

目的 探讨经主动脉瓣插管的左心室辅助方式应用于急性心力衰竭动物模型的可行性.方法 在6头猪的急性心力衰竭模型中,尝试经主动脉瓣插管的左心室辅助.并进行血流动力学及心脏超声指标的观察.结果 6头猪中有5头完成了实验.它们在血流动力学方面都显示急性心力衰竭状态的建立(P<0.05).心超指标未提示经主动脉瓣插管对主动脉瓣、二尖瓣及左心室功能的显著影响(P>0.05).在循环辅助下的血流动力学指标及部分生化指标也都较心衰状态有显著改善(P<0.05).心脏超声所示的左心室射血分数(LVEF)也有显著改善(P<0.05).结论 在急性心力衰竭模型建立后,经主动脉瓣的插管对瓣膜及左心室的功能未造成不良影响.这种循环辅助方式可以在短时间内改善急性心力衰竭的状态.

The study of the feasibility of the tansaortic cannlation in left ventricular assist by animal experiments

Objective To approach the feasibility of using the left ventricular assist by the transaortic cannulation in the acute heart failure animal model. Methods To attempt the left ventricular assist by the transaortic carmulation in 6 acute heart failure pigs. And to observe the hemodynamie and the ultrasonic cardiogram results. Results 5 of 6 pigs finished the total procedure. All of them presented the acute heart failure status by the hemodynamic results (P<0.05). The Ultrasonic cardiogram didn't show the notable effect of the transaortic cannulation on the aortic valves, the mitral valves and the left ventricu-lar function (P>0.05). Comparing with the heart failure status, the circularory assist improved the hemo-dynamic and the biochemical results (P<0. 05). The improvement of Left Ventricular Ejection Fraction (LVEF) had also been shown by the ultrasonic cardiogram (P<0.05). Conclusion It's proved by the experiments that the transaortic cannulation didn't result in harmful effects in valves and in left ventricular function after the establishment of the acute heart failure model. This type of circulatory assist can amelio-rate the acute heart failure status in short time.