Lipid-altering changes and pleiotropic effects of atorvastatin in patients with hypercholesterolemia |
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Authors: | Sakabe Koichi Fukuda Nobuo Wakayama Katsunori Nada Teru Shinohara Hisanori Tamura Yoshiyuki |
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Institution: | Department of Cardiology and Clinical Research, National Zentsuji Hospital, 2-1-1 Senyu-cho, Zentsuji, Kagawa 765-8507, Japan. ksakabe@jun.ncvc.go.jp |
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Abstract: | In this prospective study, we found beneficial short-term effects from atorvastatin therapy, including effects on low-density lipoprotein subfractions and remnant-like lipoprotein particle cholesterol, antioxidant effects, and alterations in endothelial function that may be important in early benefit from statin therapy; some effects would support much earlier benefit than previously reported. We also found long-term effects of atorvastatin, including decreased plasminogen activator inhibitor type-1 and additional significant alterations in low-density lipoprotein subfractions and endothelial function, supporting benefits from continuous long-term atorvastatin therapy beyond early reversal of hypercholesterolemia. |
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