Effects of immunonutrition on intestinal mucosal apoptosis, mucosal atrophy, and bacterial translocation in head injured rats. |
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| Authors: | Hulya Ulusoy Haydar Usul Sevim Aydin Nese Kaklikkaya Umit Cobanoglu Abdulkadir Reis Ahmet Akyol Ibrahim Ozen |
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| Affiliation: | Department of Anesthesiology and Reanimation, Black Sea Technical University, Farabi Hospital, Trabzon, Turkey |
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| Abstract: | BACKGROUND: Immunonutrition has been demonstrated to modulate gut function, reduce infectious complications, hospital stay, and ventilator days in the critical patients.AIM OF THE STUDY: We assessed the effect of immunonutrition for the prevention of intestinal mucosal atrophy, apoptosis, and bacterial translocation in head injured rats.METHODS: Thirty five rats were randomised into 5 groups. Following moderate closed head injury, in Group 1; Standard Enteral Nutrition, Group 2; Immunonutrition, Group 3; TPN, Group 4; pe. saline were applied. Group 5 was control group (chow-fed). The rats were sacrificed and segments of the ileum were removed for histologic examination, and samples of tissues taken for microbiologic evaluation.RESULTS: Both intestinal apoptosis and mucosal atrophy were significantly lower in Group 2 and Group 5 (p<0.008). Bacterial translocation was significantly lower in Group 2 than Group 1 (p<0.008).CONCLUSION: The enteral immunonutrition prevents intestinal barrier function in brain injured rats. |
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