急性胰腺炎时C-反应蛋白变化的临床意义

目的探讨急性胰腺炎病程早期C-反应蛋白(CRP)变化规律及其临床意义,为治疗及时提供依据.方法测定25例急性胰腺炎患者入院后第1、3、7、14天的外周血CRP,并与12名健康人作对照.结果(1)实验组入院第1天CRP显著高于正常对照组(P＜0.05).(2)重症组CRP高于轻症组,重症有并发症组CRP高于重症无并发症组(均P＜0.05).(3)急性胰腺炎患者血清CRP高峰值出现在发病后第3天,当CRP下降迟缓,提示并发症的发生.结论CRP可作为判断病情轻重的早期指标,并能提示并发症的发生.

The Clinical Significance of the Changes of C-Reactive Protein in Acute Pancreatitis

Objective To explore changes of C-reactive protein(CRP) and its clinical significance in the early stage of acute pancreatitis and to provide the therapeutic grounding.Methods Serum CRP of twenty-five patients were detected in the first,third and 7th and 14th day after admission and were compared with the normal control group( n =12).Results (1)CRP was significantly higher in the test group than in the normal control group on the first day after admission.(2)CRP was significantly higher in severe group than that in the mild group,as well as higher in the severe group with complications than in that without complications (all P <0.05).(3)The peak value of serum CRP in the test group was on the third day after onset.When the level of CRP decreasd slowly,complications could be predicted.Conclusion CRP could be the early index to evaluate the severity of the disease and could suggest the complications.