糖尿病患者甘油三酯/高密度脂蛋白胆固醇比值水平与胰岛素抵抗的关系

目的探讨血清甘油三酯/高密度脂蛋白胆固醇(TG/HDL-C)比值水平与胰岛素抵抗的关系。方法对146例2型糖尿病患者测定空腹胰岛素(FINS)、空腹血糖(FBG),TG,HDL-C,低密度脂蛋白胆固醇(LDL-C)水平,计算TG/HDL-C比值,并按TG/HDL-C和FBG水平分组,比较组间差异与胰岛素抵抗指数(HOMA-IR)的关系。结果糖尿病组TG/HDL-C比值水平(2.531±3.741)显著高于正常对照组(0.898±0.487),差异有显著性(t=4.279,P<0.001)。TG/HDL-C比值增高组HOMA-IR(3.291±2.004)明显高于TG/HDL-C比值正常组(2.403±1.789),差异有显著性(t=2.796,P<0.01)。血糖水平>10 mmol/L组HOMA-IR(3.575±2.216)明显大于血糖水平≤10mmol/L组(2.384±1.584),差异有显著性(t=3.760,P<0.001)。结论糖尿病患者TG/HDL-C比值水平与胰岛素抵抗存在着密切的相关性。

The Relation between Triglyceride/High Density Lipoprotein Cholesterol Ratio and Insulin Resistance in Diabetics

Objective To study the relation between triglyceride/high density lipoprotein-cholesterol(TG/HDL-C) ratio level in serum and insulin resistance(IR) in diabetes.Methods Parameters,such as fast insulin(FINS),fast blood glucose(FBG),TG,HDL-C,low density lipoprotein-cholesterol(LDL-C),were measured in 146 patients with diabetes Ⅱ.TG/HDL-C ratio was calculated.The patients were divided into several groups according to serum TG/HDL-C ratio and FBG level.Results TG/HDL-C ratio of diabetic group(2.531±3.741) was obviously higher than that of normal control group(0.898±0.487),and the difference between them was notably significant(t=4.279,P<0.001).Homostasis model assessment(HOMA)-IR(3.291±2.004) of the group whose TG/HDL-C ratio was increased was obviously higher than that(2.403±1.789) of the group with normal TG/HDL-C ratio,and the difference between them was notably significant(t=2.796,P<0.01).HOMA-IR(3.575±2.216) of the group with higher FBG level(>10 mmol/L) was higher obviously than that(2.384±1.584) of the group with lower FBG level(≤10 mmol/L),and the difference between them was notably significant(t=3.760,P<0.001).Conclusion There is a compact correlation between TG/HDL-C ratio and insulin resistance in diabetes.